Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effects of Horse Bone Extracts on the Induced Postmenopausal Osteoporosis in Rats

백서의 폐경기 골다공증 모델에서 말뼈 추출물의 효과

  • Park, Sun-Soon (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Lee, Hye-Ja (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Yoon, Weon-Jong (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Kang, Gyeoung-Jin (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Yang, Eun-Jin (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Kim, Hyo-Sun (JEJU BIO WORLD) ;
  • Choo, Chang-Su (JEJU BIO WORLD) ;
  • Kang, Hee-Kyoung (Department of Pharmacology, College of Medicine, Jeju National University) ;
  • Yoo, Eun-Sook (Department of Pharmacology, College of Medicine, Jeju National University)
  • 박선순 (제주대학교 의과대학 약리학교실) ;
  • 이혜자 (제주대학교 의과대학 약리학교실) ;
  • 윤원종 (제주대학교 의과대학 약리학교실) ;
  • 강경진 (제주대학교 의과대학 약리학교실) ;
  • 양은진 (제주대학교 의과대학 약리학교실) ;
  • 김효선 (제주바이오세상) ;
  • 추창수 (제주바이오세상) ;
  • 강희경 (제주대학교 의과대학 약리학교실) ;
  • 유은숙 (제주대학교 의과대학 약리학교실)
  • Received : 2010.07.06
  • Accepted : 2010.08.06
  • Published : 2010.09.30
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Abstract

Osteoporosis is a metabolic bone disease associated with an imbalance of bone remodeling. Osteoporosis is characterized by decreased bone mass and increased bone fractures. In this study, we investigated the effects of horse bone extracts (HBEs) in vivo. Horse bone was extracted with 80% alcohol (HBE-A) at $100^{\circ}C$ or water (HBE-W) at $120^{\circ}C$. Animal model of postmenopausal osteoporosis was used, in which osteoporosis was induced by ovariectomy of female S.D. rats (female rats were divided into 5 groups), and HBEs were administered to ovariectomized rats every day for 8 weeks. After 8 weeks, the rats were sacrificed and the following osteoporotic factors were measured: body weight, bone mineral density (BMD), uterine/body weight ratio, serum estradiol (E2), and serum alkaline phosphatase (ALP). The results showed that the administration of HBE-W decreased the changes of body weight in ovariectomized rats. HBE-W increased the uterine/body weight ratio and BMD. In addition, HBEs decreased the ALP. Therefore, HBEs may be used for the prevention or treatment of bone disease.

Keywords

References

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