YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-proliferative Effects of Daidzein, Baicalein, Hesperidin and Ursolic Acid on Human Breast Cancer Cells Stimulated by Estrogenic Compounds

에스트로겐성 물질에 의해 자극된 인간 유방암 세포 증식에 대한 다이드제인, 바이칼레인, 헤스페리딘 및 우르솔산의 억제 효과

  • Lee, Mi-Nam (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Lee, Su-Yel (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Lee, Hyun-Jae (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Seok, Jeong-Ho (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Lee, Choong-Jae (Department of Pharmacology, School of Medicine, Chungnam National University)
  • 이미남 (충남대학교 의학전문대학원 약리학교실) ;
  • 이수열 (충남대학교 의학전문대학원 약리학교실) ;
  • 이현재 (충남대학교 의학전문대학원 약리학교실) ;
  • 석정호 (충남대학교 의학전문대학원 약리학교실) ;
  • 이충재 (충남대학교 의학전문대학원 약리학교실)
  • Received : 2010.03.14
  • Accepted : 2010.03.29
  • Published : 2010.06.30
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Abstract

We investigated whether three flavonoids including daidzein, baicalein, hesperidin and ursolic acid, a triterpene acid, affect proliferation of MCF-7 human breast cancer cells stimulated by estrogenic compounds. Ursolic acid and baicalein inhibited proliferation of MCF-7 cells induced by PhIP, a food-derived carcinogen with estrogenic activity. Daidzein and hesperidin inhibited estradiol-induced proliferation of MCF-7 cells. These compounds should be further investigated for the possible involvement in signaling pathway after estrogen receptor binding in breast cancer cells.

Keywords

References

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