The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Nutritional Characteristics and Physiological Functionality of Antidementia Acetylcholinesterase Inhibitor-containing Methanol Extract from Sorghum bicolor

항치매성 아세틸콜린에스터레이즈 저해 물질을 함유한 수수(Sorghum bicolor) 메탄올 추출물의 영양학적 특성과 생리 기능성

  • Song, Jung-Eun (Dept. of Life Science and Genetic Engineering, Paichai University) ;
  • Song, Jung-Hwa (Dept. of Life Science and Genetic Engineering, Paichai University) ;
  • Cho, Soo-Muk (Dept. of Agrofood Resources, National Academy of Agricultural Science) ;
  • Min, Gyung-Hun (Dept. of Emergency Medical Technology, Woosong University) ;
  • Lee, Jong-Soo (Dept. of Life Science and Genetic Engineering, Paichai University)
  • 송정은 (배재대학교 생명유전공학과) ;
  • 송정화 (배재대학교 생명유전공학과) ;
  • 조수묵 (국립농업과학원 농식품자원부) ;
  • 민경훈 (우송대학교 응급구조학과) ;
  • 이종수 (배재대학교 생명유전공학과)
  • Received : 2010.03.02
  • Accepted : 2010.06.04
  • Published : 2010.06.30
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Abstract

새로운 항치매성 건강식품을 개발하기 위해 아세틸콜린에스터레이즈(AChE)를 강력하게 저해하는 추출물을 곡류와 두류의 다양한 추출물로부터 선발한 후 최적 추출 조건을 조사하였다. 추출물 중 수수 메탄올 추출물이 63.4%의 가장 높은 AChE 저해 활성을 보였다. 수수를 80% 메탄올로 $40^{\circ}C$에서 12시간 추출했을 때 최대의 AChE 저해 활성을 나타내었다. AChE를 저해하는 수수 메탄올 추출물의 영양성과 생리 기능성을 조사하였다. 메탄올 추출물은 유리당으로 고형물 100 g당 4.78 g의 포도당과 4.13 g의 자당 및 0.97 g의 과당을 함유하였다. 또한, 수수 메탄올 추출물의 고형물 100 g에 linoleic acid 273.82 mg, oleic acid 215.65 mg, palmitic acid 122.03 mg, stearic acid 4.96 mg을 함유하고 있었고, 주요 유기산으로 주석산 27.45 mg, 말론산 15.43 mg, 사과산 9.94 mg이 메탄올 추출물 1 g에 함유되어 있었다. 수수 메탄올 추출물은 항치매 활성 외에도 콜레스테롤 합성을 저해하는 HMG-CoA reductase 저해 활성이 50.2%이었고, 항산화 활성은 56.1%를 보였다.

Keywords

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