Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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One Pot Synthesis of Substituted [1,2,4]-Triazolo [1',2':1,2]pyrimido [6,5-b]-quinoline and Its Antibacterial Activity

  • Joshi, Ratnadeep S. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Mandhane, Priyanka G. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Chate, Asha V. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Khan, Wajid (Department of Microbiology, Maulana Azad College) ;
  • Gill, Charansingh H. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
  • Received : 2010.03.02
  • Accepted : 2010.06.30
  • Published : 2010.08.20
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Abstract

A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.

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References

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