Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis, Anthelmintic and Anti-inflammatory Activities of Some Novel Imidazothiazole Sulfides and Sulfones

  • Shetty, Nitinkumar S. (Department of Chemistry, Changwon National University) ;
  • Khazi, Imtiyaz Ahmed M. (Department of Chemistry, Karnatak University) ;
  • Ahn, Chul-Jin (Department of Chemistry, Changwon National University)
  • Received : 2010.03.02
  • Accepted : 2010.06.30
  • Published : 2010.08.20
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Abstract

A series of new 6-aryl-3-(3,4-dimethoxy-phenyl)-2-phenylsulfanyl-imidazo[2,1-b]-thiazole (5a-c) and 6-aryl-2-benzenesulfonyl-3-(3,4-dimethoxy-phenyl)imidazo[2,1-b]- thiazole (6a-c) have been prepared and characterized by analytical and spectral methods. The title compounds 5a-c and 6a-c were obtained by the reaction of 4-(3,4-dimethoxy-phenyl)-5-phenylsulfanyl-thiazol-2-ylamine (3) and 5-benzenesulfonyl-4-(3,4-dimethoxy -phenyl)thiazol-2-ylamine (4) with various phenacyl bromides in anhydrous ethanol. These newly synthesized compounds (5a-c and 6a-c) were screened for their anthelmintic and anti-inflammatory activities, where they have displayed better activities.

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References

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