Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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New Compounds from Euphorbia helioscopia and Absolute Configuration Determination by Computational Methods

  • He, Jiang-Bo (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences) ;
  • Zhu, Hua-Jie (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences) ;
  • Luo, Gui-Fen (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences) ;
  • Liu, Guang-Ming (College of Pharmaceutical Sciences, Dali University) ;
  • Chen, Hao (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences) ;
  • Li, Yan (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences) ;
  • Chen, Shaopeng (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences) ;
  • Lu, Xin (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences) ;
  • Zhou, Guochun (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences) ;
  • Cheng, Yong-Xian (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences)
  • Received : 2010.05.22
  • Accepted : 2010.06.14
  • Published : 2010.08.20
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Abstract

The whole plant of Euphorbia helioscopia is an important traditional Chinese medicine. Fom its BuOH soluble extract, one new lactam (1), three new terpenoids (2-4) including a new naturally occurring compound, and three known compounds were isolated. Their structures were identified by spectroscopic evidences. In particular, the absolute configurations of side chain of compounds 1 and 2 were determined using computational methods.

Keywords

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