Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

Effects of Punica granatum (Pomegranate) Extracts on the Menopause Women

  • 김형준 (세명대학교 제천한방병원 한방 부인/소아과) ;
  • ;
  • Received : 2010.01.29
  • Accepted : 2010.03.15
  • Published : 2010.03.31
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Abstract

A randomized, double blind, placebo-controlled human intervention study involving 58 menopause women was performed to investigate the effect of pomegranate extracts on menopausal symptoms. The volunteers were randomly distributed into two groups, one taking pomegranate extracts (1.5 g/day) and the other being a placebo by taking oral administration for 8 weeks. The results from this study showed that duration of hot flush and sweating were significantly decreased by taking pomegranate extracts. In addition, menopausal rating scales and the Kuppermann index were significantly decreased in pomegranate extract taking group. This result suggests a possibility that pomegranate extracts can be helpful for menopause women.

Keywords

References

  1. Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D, Fuhnman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Natr. 2000. 71: 1062-1076.
  2. Cauley JA, Zmuda JM, Ensrud KE, Bauer DC. Timing of estrogen replacement therapy for optimal osteoporosis prevention. J Clin Endocrinol Metab. 2001. 86: 5700-5705. https://doi.org/10.1210/jc.86.12.5700
  3. Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D, Rodabough RJ, Gilligan MA, CyrMG, Thomson CA, Khandekar J, Petrovitch Helen, McTiernan A. Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women: The Women's Health Initiative Randomized Trial. JAMA: Journal of the American Medical Association. 2003. 289(4): 3243-3253. https://doi.org/10.1001/jama.289.24.3243
  4. Choi OK, Chung KS, Cho GS, Hwang MO, Yoo YS. Proximate compositions and selected phytoestrogens of Iranian black pomegranate extract and its products. Korean J Food and Nutr. 2002. 15(2): 119-125.
  5. Kim SH, Kim IH, Kang BH, Cha TY, Lee JH, Rim SO, Song KS, Song BH, Kim JG, Lee JM. Analysis of extraction characteristics of phytoestrogen components from punica granatum L. J Korean Soc Appl Biol Chem. 2005. 48(4): 352-357.
  6. Koh JH, Hwang MO, Moon JS, Hwang SY, Son JY Antioxidative and antimicrobial activities of pomegranate seed extracts. Korean J Food Cookery Sci. 2005. 21: 171-179.
  7. Lee YH, Hyun SH, Choung SY. Effect of singled and mixed pomegranate on postmenopausal symptoms in ovariectomized rats. Yakhak Hoeji. 2006. 50: 177-183.
  8. Lemay A, Dodis S, Kodri N, Jacques H, Forst JC. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstetrics and Gynecology. 2002. 100: 495-504. https://doi.org/10.1016/S0029-7844(02)02123-3
  9. Longtin R. The pomegranate: nature's power fruit?. J Nat'l Cancer Inst. 2003. 95: 346-348. https://doi.org/10.1093/jnci/95.5.346
  10. Morishige K, Matsumoto K, Ohmichi M, Nishio Y, Adachi K, Hayakawa J, Nukui K, Tasaka K, Kurachi H, Murata Y. Clinical features affecting the results of estrogen replacement therapy on bone density in Japanese postmenopausal women. Gynecol Obstet Invest. 2001. 52: 223-226. https://doi.org/10.1159/000052979
  11. National Statistical Office. Life-table. 2002. Dae-jeon, Korea.
  12. Nugteren DH, Christ-Hazelhof E. Naturally occurring conjugated octadecatrienoic acid are strong inhibitors of prostaglandin biosynthesis. Prostaglandins 1987. 33: 403-417. https://doi.org/10.1016/0090-6980(87)90022-0
  13. Okada M, Hayashi N, Kometani M, Nakao K, Inukai T. Influences of ovariectomy and continuous replacement of $\beta$-estradiol on the tail skin temperature and behavior in the forced swimming test in rats. Jpn J pharmacol. 1997. 73: 93-96. https://doi.org/10.1254/jjp.73.93
  14. Okamoto JM, Yoko OH, Hideyuki Y, Hiroyuki Y. Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol. 2004. 92: 93-101. https://doi.org/10.1016/j.jep.2004.02.006
  15. Park CY. Management of later diseases in climacteric women. J Kyung Hee Univ. Med. Center. 2001. 17(1): 19-30.
  16. Poyranzogle E, Gokmen V, Artjk N. Organic acids and phenolic compounds in pomegranates grown in turkey. J Food composition analysis. 2002. 15: 567-575. https://doi.org/10.1016/S0889-1575(02)91071-9
  17. Song BH, Tran NA, Bae SY. Pomegranate as resource of phytoestrogen and anticancer substances. Kor. J. Microbiol. Biotechnol. 2007. 35(2): 81-97.
  18. 이혜숙, 갱년기 여성의 호르몬 대체요법 경험에 관한 연구. 2001. 11. 중앙대 대학원 박사학위논문. 서울, 대한민국.
  19. 한의부인과학 편찬위원회. 한의부인과학(상). 2001. 218-234. 도서출판 정담. 서울, 대한민국.