The Korean Journal of Pesticide Science (농약과학회지)

The Korean Society of Pesticide Science (한국농약과학회)
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Evaluation of Acute Toxicity of Plant Extracts, Lavender, Lemon Eucalyptus and Cassia Essential Oil

식물 추출물 라벤더, 레몬 유칼립투스 및 계피 오일의 급성독성평가

  • Jeong, Mi-Hye (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kwon, Mi-Jeong (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Park, Soo-Jin (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Hong, Soon-Sung (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Park, Kyung-Hun (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Park, Jae-Eup (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Yeon, Sung-Hum (NaturoBiotech Research Institute, NaturoBiotech Co., Ltd.)
  • 정미혜 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 권미정 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박수진 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 홍순성 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박경훈 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박재읍 (농촌진흥청 국립농업과학원 농산물안전성부 농자재평가과) ;
  • 연성흠 ((주)내츄로바이오텍 내츄로바이오텍 연구소)
  • Received : 2010.09.20
  • Accepted : 2010.11.15
  • Published : 2010.12.31
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Abstract

The acute toxicity test of high bio-active plant essential oils was conducted with Lavender, Lemon eucalyptus and Cassia oils selected to develop environment-friendly insecticides. The results of acute oral toxicity using rats showed that $LD_{50}$ of over 2,000 mg/kg bw for Lavender, Lemon eucalyptus and Cassia oils. The calculated acute dermal $LD_{50}$ value of all testing materials was over 4,000 mg/kg bw. The Skin irritation test indicated that Lavender and Lemon eucalyptus oil have no irritation while Cassia oil has a moderate irritation. For the Eye Irritation test, the result showed no irritation for Lavender and Lemon Eucalyptus oil and irritation for Cassia oils. However, the irritation was not showed for Eye Irritationwashing test of Cassia oil. Consequently, the Lavender and Lemon eucalyptus oils were showed to be low in toxicity whereas Cassia oil indicated to cause a moderate irritation on the skin and eyes.

본 연구는 생리활성이 높은 식물오일의(라벤더, 레몬유칼립투스 및 계피 오일) 친환경 살충소재의 활용가능성을 탐색하고자 급성독성(급성경구독성, 급성경피독성, 피부자극성 및 안점막자극성)시험을 수행하였다. 랫드를 이용한 급성경구독성시험결과 라벤더, 레몬 유칼립투스 및 계피 오일의 $LD_{50}$은 2,000 mg/kg bw 이상이었고, 급성경피독성시험결과 모든 시험물질의 $LD_{50}$이 4,000 mg/kg bw으로 나타났다. 피부자극성시험결과 라벤더와 레몬 유칼립투스 오일은 자극성이 없었고, 계피 오일은 중도의 자극성을 나타냈다. 안점막자극성시험결과 라벤더, 레몬 유칼립투스 오일은 자극성이 없었고, 계피오일은 중도의 자극성을 나타냈으나 세척시험 결과 자극성은 없었다. 따라서, 라벤더 및 레몬 유칼립투스 오일은 독성이 낮았으나, 계피 오일은 중도의 피부자극성 및 안점막자극성을 갖는 것으로 평가되었다.

Keywords

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