Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Supramolecular Micelle from Amphiphilic Mn(III)-porphyrin Derivatives as a Potential MRI Contrast Agent

  • Published : 2010.03.20
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Abstract

Amphiphilic porphyrin derivatives have been synthesized and characterized by $^1H$ NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UV-vis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The $T_1$ relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a $T_1$ contrast agent.

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