Fermented Soybean Powder Reduces Body Weight Gain and Improves Hepatic Lipid Accumulation in High Fat Diet-Fed Obese Male C57BL/6N Mice

고지방식이 마우스 비만모델에서 발효대두파우더의 체중증가량 변화와 지방간 개선

  • Tsung, Pei-Chin (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Lee, Hee-Young (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Lee, Hye-Rim (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Jeong, Hae-Gyeong (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University) ;
  • Yin, Yuan-Mi (Dept. of Social Welfare, College of Social Science, Dong-Guk University) ;
  • Yoon, Mi-Chung (Dept. of Life Sciences, Mok-Won University) ;
  • Park, Sun-Dong (Dept. of Formula Science, College of Oriental Medicine, Dong-Guk University) ;
  • Shin, Soon-Shik (Dept. of Formula Science, College of Oriental Medicine & Research Institute of Oriental Medicine, Dong-Eui University)
  • 총배금 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 이희영 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 이혜림 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 정해경 (동의대학교 한의과대학 방제학교실 및 한의학연구소) ;
  • 윤연미 (동국대학교 사회과학대학 사회복지학과) ;
  • 윤미정 (목원대학교 바이오건강학부) ;
  • 박선동 (동국대학교 한의과대학 방제학교실) ;
  • 신순식 (동의대학교 한의과대학 방제학교실 및 한의학연구소)
  • Received : 2010.11.27
  • Accepted : 2010.12.08
  • Published : 2010.12.30

Abstract

Objectives : We investigated the effects of fermented soybean(FSOB) on body weight and examined whether hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, FSOB(1), (2) and (3). After mice were treated with FSOB for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Results : 1. Compared with controls, FSOB-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in FSOB(3) and FSOB(1). 2. Compared with controls, FSOB-treated mice had lower feeding efficiency ratio and blood plasma leptin levels, the magnitude of which was prominent in FSOB(3). 3. Compared with controls, FSOB-treated mice had lower blood plasma total cholesterol and LDL-cholesterol levels. 4. Blood plasma AST and ALT concentrations were not changed by FSOB, indicating FSOB do not show any toxic effects. 5. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by FSOB, whereas the adipocyte number per unit area was significantly increased, suggesting that FSOB decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by FSOB. Conclusions : These results demonstrate that FSOB effectively reduces body weight gain, feeding efficiency ratio, blood plasma leptin level and improves hepatic lipid accumulation.

Keywords

References

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