Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of FLOS LONICERAE Water Extract On Anti-Rheumatiod Arthritis

금은화(金銀花)의 항(抗)류마티즘 효능(效能)에 대한 연구(硏究)

  • Kim, Hee-Soo (Jin-Sol Oriental Clinic) ;
  • Ki, Ho-Pil (Dept. of Oriental Medicine Prescription, Wonkwang University) ;
  • Lee, Joon-Suh (Dept. of Oriental Medicine Prescription, Wonkwang University) ;
  • Yun, Yong-Gab (Dept. of Oriental Medicine Prescription, Wonkwang University)
  • 김희수 (진솔한의원) ;
  • 기호필 (원광대학교 한의과대학 방제학교실) ;
  • 이준서 (원광대학교 한의과대학 방제학교실) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실)
  • Received : 2010.11.25
  • Accepted : 2010.12.06
  • Published : 2010.12.30
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Abstract

Rheumatoid arthritis is characterized by the focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce inflammatory mediators, such as interleukin-1beta(IL-$1{\beta}$), IL-6, tumour necrosis factor alpha(TNF-$\alpha$), prostaglandin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extract from FLOS LONICERAE(FLWE) in vitro and in vivo. Extract inhibited the production of inflammatory mediators(NO, IL-$1{\beta}$, TNF-$\alpha$, and prostaglandin $E_2$) and the expression of inducible NO synthase(iNOS) and cyclooxygenase-2(COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a dose-dependent manner. FLWE also inhibited TNF-$\alpha$, IL-$1{\beta}$, IL-6, and $PGE_2$ production as well as COX activity in collagen-induced mouse arthritis. Moreover, FLWE significantly suppressed collagen-induced mouse arthritis. These results suggest that FLOS LONICERAE may be useful for therapy against inflammatory immune diseases and rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.

Keywords

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