Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
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Searching of the Potent Pig Pheromonal Odorants by Receptor Based Approach

수용체 접근방법에 의한 잠재적인 돼지 페로몬 성 냄새 물질의 탐색

  • Joo, Sung-Mo (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University) ;
  • Cho, Yun-Gi (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University) ;
  • Park, Chang-Sik (Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Sung, Nack-Do (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University)
  • 주성모 (충남대학교 농업생명과학대학 응용생물환경화학과) ;
  • 조윤기 (충남대학교 농업생명과학대학 응용생물환경화학과) ;
  • 박창식 (충남대학교 형질전환복제돼지연구센터) ;
  • 성낙도 (충남대학교 농업생명과학대학 응용생물환경화학과)
  • Received : 2005.05.17
  • Accepted : 2010.08.18
  • Published : 2010.09.30
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Abstract

To search the potent pig pheromonal odorants through receptor-based approach methods, molecular dockings between 680 Flavomets as substrate molecule and pig odorants binding proteins OBP (1HQP) and PBP (1GM6) as receptor, and QSPR (quantitative structure-property relationship) analyses from physico-chemical parameters of Flavomets and their docking scores (DS) were performed and discussed quantitatively. From the basis on the findings, the optimal value $(MSA)_{opt.}=407.595\;{\AA}^2$ of MSA (molecular surface area; ${\AA}$), and RB (number of rotational bond) had the Flavomets will be able to increase DS. Therefore, it is expected that the stearyl alcohol from DS and H-bond type between substrate and receptor would be shows the character as potent pig pheromonal odorant.

Keywords

References

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