Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Delayed Detected Unexpected Complication of ADCON-$L^{(R)}$ Gel in Lumbar Surgery

  • Kim, Sung-Bum (Department of Neurosurgery, School of Medicine, Kyung Hee University) ;
  • Lim, Young-Jin (Department of Neurosurgery, School of Medicine, Kyung Hee University)
  • Received : 2010.04.05
  • Accepted : 2010.09.09
  • Published : 2010.09.28
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Abstract

The ADCON-L $gel^{(R)}$ (Gliatech, Cleveland, OH, USA), a carbohydrate polymer gel. has been shown in a controlled clinical study to inhibit postsurgical adhesions and improve a patient's clinical outcome. Immediate complication of this gel has been reported in the recent literature including back pain, radiculitis and durotomy. However, delayed detection of disturbance of muscle healing and attachment in late postoperative state has been rarely reported. This report documents an unexpected delayed detected complication of the anti-adhesion barrier gel. which was used after lumbar discectomy one year ago, with review of literature.

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References

  1. Choe IS : Therapeutic Results of CSF Leakage due to Unintended Incidental Durotomy in Spine Surgery. J Korean Neurosurg Soc 35 : 574-578, 2004
  2. de Tribolet N, Porchet F, Lutz TW, Gratzl O, Brotchi J, van Alphen HA, et al. : Clinical assessment of a novel antiadhesion barrier gel : prospective, randomized, multicenter, clinical trial of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms after lumbar discectomy. Am J Orthop 27 : 111-120, 1998
  3. Hieb LD, Stevens DL : Spontaneous postoperative cerebrospinal fluid leaks following application of anti-adhesion barrier gel : case report and review of the literature. Spine (Phila Pa 1976) 26 : 748-751, 2001 https://doi.org/10.1097/00007632-200104010-00009
  4. Kalogrianitis S, Barrett P, Shackleford I : ADCON-L and hypotension during lumbar microdiscectomy. Br J Anaesth 87 : 770-771, 2001 https://doi.org/10.1093/bja/87.5.770
  5. Kuhn J, Hofmann B, Knitelius HO, Coenen HH, Bewermeyer H : Bilateral subdural haematomata and lumbar pseudomeningocele due to a chronic leakage of liquor cerebrospinalis after a lumbar discectomy with the application of ADCON-L gel. J Neurol Neurosurg Psychiatry 76 : 1031-1033, 2005 https://doi.org/10.1136/jnnp.2004.046276
  6. Le AX, Rogers DE, Dawson EG, Kropf MA, De Grange DA, Delamarter RB : Unrecognized durotomy after lumbar discectomy : a report of four cases associated with the use of ADCON-L. Spine (Phila Pa 1976) 26 : 115-117, 2001 https://doi.org/10.1097/00007632-200101010-00020
  7. Mastronardi L, Pappagallo M, Puzzilli F, Tatta C : Efficacy of the morphine-Adcon-L compound in the management of postoperative pain after lumbar microdiscectomy. Neurosurgery 50 : 518-524, 2002
  8. Petrie JL, Ross JS : Use of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms following lumbar disc surgery : a preliminary report. Eur Spine J 5 Suppl 1 : S10-S17, 1996
  9. Richter HP, Kast E, Tomczak R, Besenfelder W, Gaus W : Results of applying ADCON-L gel after lumbar discectomy : the German ADCON-L study. J Neurosurg 95 : 179-189, 2001
  10. Zou X, Li H, Egund N, Lind M, Bünger C : Inhibition of spinal fusion by use of a tissue ingrowth inhibitor. Eur Spine J 13 : 157-163, 2004 https://doi.org/10.1007/s00586-003-0645-5

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