Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effective Partial Alkynylation of Carboxylic Acid Derivatives to Alkynyl Ketones

  • Yim, Sang-Jun (Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology) ;
  • Kim, Min-Hyeok (Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology) ;
  • An, Duk-Keun (Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology)
  • Published : 2010.02.20
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Abstract

The reaction of carboxylic acid derivatives such as esters, acid chlorides and acid anhydrides with alkynyl lithiums in the presence of lithium morpholinide and $BF_3{\cdot}OEt_2$ gave alkynyl ketones in good yield (73-96%).

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References

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  2. An Efficient Protocol for the Preparation of Ynones from Esters and Acid Chlorides vol.39, pp.5, 2018, https://doi.org/10.1002/bkcs.11450
  3. ChemInform Abstract: Effective Partial Alkynylation of Carboxylic Acid Derivatives to Alkynyl Ketones. vol.41, pp.30, 2010, https://doi.org/10.1002/chin.201030071