Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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A Hospital-Based Serological Survey of Cryptosporidiosis in the Republic of Korea

  • Lee, Jong-Kyu (Department of Environmental and Tropical Medicine, Konkuk University School of Medicine) ;
  • Han, Eun-Taek (Department of Parasitology, Kangwon National University College of Medicine) ;
  • Huh, Sun (Department of Parasitology, College of Medicine, Hallym University) ;
  • Park, Woo-Yoon (Department of Radiation Oncology, College of Medicine, Chungbuk National University) ;
  • Yu, Jae-Ran (Department of Environmental and Tropical Medicine, Konkuk University School of Medicine)
  • Published : 2009.09.30
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Abstract

The seroprevalence of cryptosporidiosis was examined using patients' sera collected from hospitals located in 4 different areas of the Republic of Korea. ELISA was used to measure antibody titers against Cryptosporidium parvum antigens from a total of 2,394 serum samples, which were collected randomly from patients in local hospitals; 1)Chungbuk National University Hospital, 2) Konkuk University Hospital, 3) local hospitals in Chuncheon, Gangwon-do (province), 4) Jeonnam National University Hospital, from 2002 through 2003. Of the2,394 samples assayed, 34%, 26%, and 56% were positive for C. parvum-specific IgG, IgM, and IgA antibodies, respectively, Positive IgG titers were most common in sera from Jeonnam National University Hospital, Gwangju, Jeollanam-do, and positive IgM titers were most common in sera from Chungbuk National University Hospital, Cheongju, Chuncheonqbuk-do. The seropositivity was positively correlated with age for both the IgG and IgA antibodies but was negatively correlated with age for the IgM antibodies. Western blotting revealed that 92%, 83%, and 77% of sera positive for IgG, IgM, and IgA ELISA reacted with 27-kDa antigens, respectively. These results suggested that infection with Cryptosporidium in hospital patients occurs more commonly than previously reported in the Republic of Korea.

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References

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