Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Congenital Cystic Adenomatoid Malformation of the Lng with Atypical Adenomatous Hyperplasia in Adult

성인에서 발견된 비정형 샘 증식증과 동반된 폐의 선천성 낭성 선종양 기형 1예

  • Lee, Ho Sung (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Choi, Jae Sung (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Seo, Ki Hyun (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Na, Ju Ock (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Kim, Yong Hoon (Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Oh, Mi Hye (Department of Diagnostic Pathology Soonchunhyang University Cheonan Hospital, College of Medicine) ;
  • Jou, Sung Shick (Department of Radiology Soonchunhyang University Cheonan Hospital, College of Medicine)
  • 이호성 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 최재성 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 서기현 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 나주옥 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 김용훈 (순천향대학교 의과대학 천안병원 내과학교실) ;
  • 오미혜 (순천향대학교 의과대학 천안병원 진단병리학교실) ;
  • 조성식 (순천향대학교 의과대학 천안병원 방사선과학교실)
  • Received : 2009.02.20
  • Accepted : 2009.05.22
  • Published : 2009.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Congenital cystic adenomatoid malformation (CCAM), which is classified into five types according to size and bronchial invasion, is a rare type of developmental anomaly of the lung. CCAM is occasionally accompanied by malignancy, such as bronchioloalveolar carcinoma (BAC) or rhabdomyosarcoma. As defined by the WHO, atypical adenomatous hyperplasia (AAH) is a non-invasive spread of atypical epithelial cells in single rows along the alveolar wall, within a lesion that is usually less than 5 mm in diameter. AAH was also regarded as a pre-invasive neoplasia, especially associated with BAC and adenocarcinoma. We report a case of type II CCAM with AAH in adults, with a review of the references.

저자들은 성인에서 객혈을 동반한 폐의 선천성 낭성 선 종양 기형과 전암 병변인 비정형 샘 증식증의 동반 발병을 경험하였기에 보고하는 바이다.

Keywords

References

  1. Seo JS, Lee YC, Rhee YK. A case of congenital cystic adenomatoid malformation in adult patient. Korean J Med 1993;45:104-8
  2. Stocker JT. Congenital and developmental diseases. In: Dali DH, Hammar SP, editors. Pulmonary pathology. 2nd ed. New York: Springer-verlag; 1994. p. 155-90
  3. Kim JI, Oh BJ, Song MH, Yun JP, Kim SH, Do KH, et al. Congenital cystic adenomatoid malformation of the lung presenting as hemoptysis in 49-year-old woman: a case report. Korean J Crit Care Med 2004;19:139-42
  4. Weng S, Tsuchiya E, Satoh Y, Kitagawa T, Nakagawa K, Sugano H. Multiple atypical adenomatous hyperplasia of type II pneumonocytes and bronchiolo-alveolar carcinoma. Histopathology 1990;16:101-3 https://doi.org/10.1111/j.1365-2559.1990.tb01073.x
  5. Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J 2001;18:1059-68 https://doi.org/10.1183/09031936.01.00275301
  6. Chapman AD, Kerr KM. The association between atypical adenomatous hyperplasia and primary lung cancer. Br J Cancer 2000;83:632-6 https://doi.org/10.1054/bjoc.2000.1317
  7. Stocker JT, Madewell JE, Drake RM. Congenital cystic adenomatoid malformation of the lung: classification and morphologic spectrum. Hum Pathol 1977;8:155-71 https://doi.org/10.1016/S0046-8177(77)80078-6
  8. Shackelford GD, Siegel MJ. CT appearance of cystic adenomatoid malformations. J Comput Assist Tomogr 1989;13:612-6 https://doi.org/10.1097/00004728-198907000-00010
  9. Ioachimescu OC, Mehta AC. From cystic pulmonary airway malformation, to bronchioloalveolar carcinoma and adenocarcinoma of the lung. Eur Respir J 2005;26:1181-7 https://doi.org/10.1183/09031936.05.00011705
  10. Kerr KM. Pulmonary preinvasive neoplasia. J Clin Pathol 2001;54:257-71 https://doi.org/10.1136/jcp.54.4.257
  11. Kawakami S, Sone S, Takashima S, Li F, Yang ZG, Maruyama Y, et al. Atypical adenomatous hyperplasia of the lung: correlation between high resolution CT findings and histopathologic features. Eur Radiol 2001;11:811-4 https://doi.org/10.1007/s003300000790
  12. Yokose T, Doi M, Tanno K, Yamazaki K, Ochiai A. Atypical adenomatous hyperplasia of the lung in autopsy cases. Lung Cancer 2001;33:155-61 https://doi.org/10.1016/S0169-5002(01)00198-2
  13. Yokose T, Ito Y, Ochiai A. High prevalence of atypical adenomatous hyperplasia of the lung in autopsy specimens from elderly patients with malignant neoplasms. Lung Cancer 2000;29:125-30
  14. Nakahara R. Yokose T, Nagai K, Nishiwaki Y, Ochiai A. Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia. Thorax 2001;56:302-5 https://doi.org/10.1136/thorax.56.4.302
  15. Takigawa N, Segawa Y, Nakata M, Saeki H, Mandai K, Kishino D, et al. Clinical investigation of atypical adenomatous hyperplasia of the lung. Lung Cancer 1999;25:115-21 https://doi.org/10.1016/S0169-5002(99)00055-0