DOI QR코드

DOI QR Code

Gastric Metastasis of Primary Lung Adenocarcinoma Mistaken for Primary Gastric Cancer

원발성 위암으로 오인된 전이성 비소세포 폐암 1예

  • Park, Young Sik (Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
  • Lee, Jin Woo (Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
  • Lim, Hyo-Jeong (Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
  • Lee, Geon Kook (Center for Lung Cancer, National Cancer Center) ;
  • Hwangbo, Bin (Center for Lung Cancer, National Cancer Center) ;
  • Lee, Hee Seok (Center for Lung Cancer, National Cancer Center)
  • 박영식 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
  • 이진우 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
  • 임효정 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
  • 이건국 (국립암센터 폐암센터) ;
  • 황보빈 (국립암센터 폐암센터) ;
  • 이희석 (국립암센터 폐암센터)
  • Received : 2008.10.12
  • Accepted : 2008.11.05
  • Published : 2009.01.30

Abstract

The stomach is a rare site for metastasis, with autopsy incidence rates of 0.2% to 1.7%. This low rate makes diagnosis of metastatic gastric cancer challenging for clinicians. The authors report a case of a 64-year-old man diagnosed with gastric metastasis of primary lung adenocarcinoma that was initially mistaken for primary gastric cancer, as well as a review of the medical literature.

전이성 위암은 발생 빈도가 매우 낮으며, 부검 연구를 통한 발생률은 0.2%에서 1.7%으로 알려져 있다. 전이성 위암과 원발성 위암은 육안으로 구별되지 않으며, 특히 병리학적으로 선암이 나온 경우 임상적 문제가 발생할 수 있다. 64세 남자 환자가 외부병원에서 객혈을 토혈로 오인하여 우연히 발견하게 된 위악성종양에 대해 위부분절 제술을 먼저 시행 받았다가, 이후에도 지속된 객혈로 폐암이 발견되어 다시 폐엽절제술을 시행 받은 후, 다시 재발한 폐암으로 본원을 방문하였다가 면역조직화학염색을 통해 최초의 위암이 폐암의 위 전이였음을 확인한 드문 예를 경험하여 이를 보고한다.

Keywords

References

  1. Kadakia SC, Parker A, Canales L. Metastatic tumors to the upper gastrointestinal tract: endoscopic experience. Am J Gastroenterol 1992;87:1418-23
  2. Menuck LS, Amberg JR. Metastatic disease involving the stomach. Am J Dig Dis 1975;20:903-13 https://doi.org/10.1007/BF01070875
  3. Wu MH, Lin MT, Lee PH. Clinicopathological study of gastric metastases. World J Surg 2007;31:132-6 https://doi.org/10.1007/s00268-006-0177-3
  4. Green LK. Hematogenous metastases to the stomach: a review of 67 cases. Cancer 1990;65:1596-600 https://doi.org/10.1002/1097-0142(19900401)65:7<1596::AID-CNCR2820650724>3.0.CO;2-5
  5. Oda, Kondo H, Yamao T, Saito D, Ono H, Gotoda T, et al. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy 2001;33:507-10 https://doi.org/10.1055/s-2001-14960
  6. Hsu CC, Chen JJ, Changchien CS. Endoscopic features of metastatic tumors in the upper gastrointestinal tract. Endoscopy 1996;28:249-53 https://doi.org/10.1055/s-2007-1005437
  7. Campoli PM, Ejima FH, Cardoso DM, Silva OQ, Santana Filho JB, Queiroz Barreto PA, et al. Metastatic cancer to the stomach. Gastric Cancer 2006;9:19-25 https://doi.org/10.1007/s10120-005-0352-5
  8. Kim HS, Jang WI, Hong HS, Lee CI, Lee DK, Yong SJ, et al. Metastatic involvement of the stomach secondary to lung carcinoma. J Korean Med Sci 1993;8:24-9 https://doi.org/10.3346/jkms.1993.8.1.24
  9. Kim HG, Kim YS, Choi SD, Won YJ, Jung JH, Sue YB, et al. A case of squamous cell lung cancer with metastasis of the stomach. Korean J Gastrointest Endosc 1998;18:900-7
  10. Civitareale D, Lonigro R, Sinclair AJ, Di Lauro R. A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J 1989;8:2537-42
  11. Moldvay J, Jackel M, Bogos K, Soltesz I, Agocs L, Kovacs G, et al. The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. Pathol Oncol Res 2004;10:85-8 https://doi.org/10.1007/BF02893461
  12. Roh MS, Hong SH. Utility of thyroid transcription factor-1 and cytokeratin 20 in identifying the origin of metastatic carcinomas of cervical lymph nodes. J Korean Med Sci 2002;17:512-7
  13. Su YC, Hsu YC, Chai CY. Role of TTF-1, CK20, and CK7 immunohistochemistry for diagnosis of primary and secondary lung adenocarcinoma. Kaohsiung J Med Sci 2006;22:14-9 https://doi.org/10.1016/S1607-551X(09)70214-1
  14. Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 2003;27:303-10 https://doi.org/10.1097/00000478-200303000-00003
  15. Park SY, Kim BH, Kim JH, Lee S, Kang GH. Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med 2007;131:1561-7

Cited by

  1. Adenocarcinoma of Lung Cancer with Solitary Metastasis to the Stomach vol.64, pp.3, 2009, https://doi.org/10.4166/kjg.2014.64.3.154