Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

In Vivo Toxicity and Anti-Tumor Activity of Korean Mistletoe Extracts

한국산 겨우살이 추출물의 in vivo 독성 및 항종양 효과

  • Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University) ;
  • Park, Sung-Min (Institute for Biomedical Research, Han-Dong University) ;
  • Yang, Seung-Hoon (Institute for Biomedical Research, Han-Dong University) ;
  • Jung, Hoe-Yune (Institute for Biomedical Research, Han-Dong University) ;
  • Lee, An-Na (Institute for Biomedical Research, Han-Dong University) ;
  • Yoo, Yung-Choon (Department of Biochemistry, College of Medicine, Konyang University) ;
  • Kang, Tae-Bong (Institute for Biomedical Research, Han-Dong University) ;
  • Kim, Jong-Bae (Institute for Biomedical Research, Han-Dong University)
  • 윤택준 (유한대학 식품영양과) ;
  • 박성민 (한동대학교 생의학연구소) ;
  • 양승훈 (한동대학교 생의학연구소) ;
  • 정회윤 (한동대학교 생의학연구소) ;
  • 이안나 (한동대학교 생의학연구소) ;
  • 유영춘 (건양대학교 의과대학) ;
  • 강태봉 (한동대학교 생의학연구소) ;
  • 김종배 (한동대학교 생의학연구소)
  • Published : 2009.09.30
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Abstract

Antitumor activity of Korean mistletoe extract (KM-110) and European commercial mistletoe preparation (Helixor) was investigated. KM-110 showed the cytotoxic effect that it is high for various tumor cell lines and normal splenocytes in comparison with Helixor. Administration of two mistletoe extracts ($100{\mu}g$) to mice did not show any significant changes on the level of glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvate transaminase (GTP), blood creatinine (CRE) and blood urea nitrogen (BUN) in sera. The culture supernatant of macrophages stimulated with KM-110 inhibited effectively tumor growth whereas Helixor had little effect. Administration of KM-110 or Helixor resulted in a effective inhibition of lung metastasis after the i.v. inoculation of colon 26-M3.1 lung carcinoma, B16-BL6 melanoma and L5178Y-ML25 lymphomas. In all cases, the mice treated with KM-110 showed more effective anti-tumor metastatic activity than the mice of Helixor. These results suggest that Korean mistletoe extracts, KM-110 might be used as an alternative methods having antitumor activity like European mistletoe preparation, Helixor.

Keywords

References

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