Food Science and Biotechnology

  • 제18권3호
  • /
  • Pages.813-817
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  • 2009
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  • 1226-7708(pISSN)
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  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage

  • Pan, Cheol-Ho (Natural Products Research Center, Korea Institute of Science and Technology Gangneung Branch) ;
  • Kim, Eun-Sun (Department of Science Education (Biology), College of Education, Chungbuk National University) ;
  • Um, Byung-Hun (Natural Products Research Center, Korea Institute of Science and Technology Gangneung Branch) ;
  • Lee, Jae-Kwon (Department of Science Education (Biology), College of Education, Chungbuk National University)
  • 발행 : 2009.06.30
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초록

The effect of 4 seaweed extracts (Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, and Ishige okamurae) on pro-inflammatory mediators as well as nuclear factor $(NF)-{\kappa}B$ in the stimulated Raw 264.7 cells was investigated. They reduced iNOS and interlukin $(IL)-1{\beta}$ expressions at transcription level. Of those, 3 extracts (D. divaricata, I. okamurae, and S. lomentaria) inhibited the COX-2 expression at translation level. $I{\kappa}B-{\alpha}$ degradation was inhibited by D. divaricata and S. lomentaria extracts. Therefore, we concluded that the extracts from D. divaricata and S. lomentaria could inhibit the activation of murine macrophage through the blocking of $NF-{\kappa}B$ activation.

키워드

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