Korean Journal of Adult Nursing (성인간호학회지)

Korean Society of Adult Nursing (한국성인간호학회)
권호 표지

Cardiovascular Risk Factors Predicting Endothelial Dysfunction in Patients with Variant Angina

이형협심증 환자의 혈관내피세포 기능저하에 영향을 미치는 심혈관질환 위험인자

  • Cho, Sook-Hee (The Heart Center of Chonnam National University Hospital) ;
  • Hwang, Seon-Young (Department of Nursing, College of Medicine, Chosun University) ;
  • Jeong, Myung-Ho (The Heart Center of Chonnam National University Hospital)
  • 조숙희 (전남대학교병원 심장센터 심초음파실) ;
  • 황선영 (조선대학교 의과대학 간호학과) ;
  • 정명호 (전남대학교병원 심장센터)
  • Received : 2009.07.07
  • Accepted : 2009.10.08
  • Published : 2009.10.31
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Abstract

Purpose: This study was conducted to identify the clinical characteristics and risk factors on the occurrence of variant angina, and to examine the predicting factors on the vascular endothelial dysfunction of the patients with variant angina. Methods: A total of 134 patients diagnosed with variant angina were recruited from 2006 to 2008. The degrees of endothelial dysfunction were measured and recorded by the researcher using the values of flow-mediated vasodilation of their brachial arteries and Nitroglycerine-mediated dilation. Subjects' demographic data and risk factors were gathered after obtaining informed consent, and their electronic medical records were reviewed to collect laboratory data. Results: The mean age was $54.2{\pm}9.6$ years and 52% was male patients. More than 50% of the male patients were cigarette smokers and had hypercholesterolemia. 84% of the male patients and 70% of the female patients had more than one risk factor of cardiovascular disease. A stepwise multiple regression analysis showed that smoking and hypercholesterolemia predicted the decrease of flow-mediated vasodilation (Adjusted $R^2$ = .204, p < .001). Conclusion: Tailored educational interventions for smoking cessation and cholesterol management are needed to prevent recurrence of angina attack for patients with variant angina and to prevent cardiovascular disease for middle-aged workers.

Keywords

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