The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Anti-inflammaory effects of the MeOH extract of Humulus japonicus in vitro

율초(葎草) 추출물이 Rat의 paw edema에 미치는 영향

  • 황순이 (대구한의대학교 한의과대학 안이비인후피부과교실) ;
  • 정호준 (대구한의대학교 한의과대학 안이비인후피부과교실) ;
  • 장우석 (대구한의대학교 한의과대학 내과학교실) ;
  • 조미정 (대구한의대학교 한의과대학 방신약개발팀 (BK21 Team)) ;
  • 김상찬 (대구한의대학교 한의과대학 방신약개발팀 (BK21 Team)) ;
  • 지선영 (대구한의대학교 한의과대학 안이비인후피부과교실)
  • Received : 2009.10.31
  • Accepted : 2009.11.30
  • Published : 2009.12.25
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Abstract

Objectives : The present study was examined to evaluate the anti-inflammatory effects of the Humulus japonicus MeOH extracts (HJE) in the carrageenan-induced paw edema model in rats. Methods : The effects of HJE on anti-inflammation were measured in the carrageenan-induced paw edema model in rats and infiltrated Inflammatory Cells. Results : 1. HJE (1.0 g/kg) and dexamethasone effectively inhibited paw edema measured 1~4 h after carrageenan injection. HJE (0.3 g/kg) effectively inhibited paw edema measured 1, 3, 4 hr. 2. In histopathological study in rats, 1.0 g/kg HJE and dexamethasone effectively inhibited the increases of hind paw skin thicknesses and inflammatory cell infiltrations induced by carrageenan treatment. But quite similar histopathological changes were detected in 0.3 g/kg HJE treated group as compared with carrageenan control.

Keywords

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