The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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The Effects of Ethosome and Liposome Formulation Entrapped DL-HGF to Hair Growth Activity in Animal Model

DL-HGF를 주성분으로 한 ethosome 및 liposome 제형화합물이 발모 촉진 활성에 미치는 영향

  • 김현우 (세명대학교 천연자원의약연구소) ;
  • 정용준 (세명대학교 천연자원의약연구소) ;
  • 이동규 (충북대학교 공업화학과) ;
  • 한상근 ((주)한국콜마) ;
  • 정의수 ((주)더마랩) ;
  • 김희택 (세명대학교 한의과대학 안이비인후피부과학교실) ;
  • 강세찬 (세명대학교 자연약재과학과)
  • Published : 2009.04.25
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Abstract

Objectives : To investigate the effects of DL-HGF to hair growth activity in mouse, various kinds of ethosome and liposome formulations entrapped DL-HGF were produced and this study was carried out. Methods : The B16/BL6 mice were classified into five groups: vehicle control (Con) group, Et-1-applied group, Et-2-applied group, LP-1-applied group, LP-2-applied group. Active hair growth (anagen) was induced in the back skin by application of a waxosin mixture with subsequent depilation and the activity of hair growth was measured by macroscopic observation and histology. Results : In vehicle control group, there was no hair growth activity during experiment period. In Et-1-applied group, the rate of hair growth was about 100%, LP-1-applied group and Et-2-applied group showed 70-80% and 40-50% of hair growth rates, respectively. The rate of hair growth of LP-2-applied group was lower than other applied groups (20-30%). In H/E staining, Numerous hair folicles and hair shafts were observed in Et-1-applied group and other groups showed lower level of hair folicles and hair shafts formation than Et-1-applied group, Conclusion : Et-1 formulation showed highest hair growth activity than other ethosome and liposome formulations entrapped DL-HGF.

Keywords

References

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