The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Anti-metastatic and Immunomodulating Activity of Water-Soluble Components from Five Mushroom Extracts

  • Yoo, Hwa-Seung (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Han, Sung-Soo (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Kim, Jung-sun (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Cho, Chong-Kwan (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yeon-Weol (Department of East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Park, Sang-Yong (R&D Lab. of Bulrolife Co., Ltd.) ;
  • Lee, Soo-Jin (Department of Physiology, College of Oriental Medicine, Sangji University)
  • Published : 2009.05.30
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Abstract

Objectives : This experiment was conducted to evaluate the inhibitory effects against lung metastasis and promotion of splenocytes by water-soluble components from five mushrooms extracts (WEFM): Garnoderma frondosa, Corious versicolor, Codyceps militaris, Hericium erinaceus and Lentinula edodes. Methods : Colon 26-L5 carcinoma cells were injected through the tail vein to induce lung metastatic cancer. Changes in weight of lung were observed and cytokine level was analyzed to evaluate immunological changes. Results : Oral administration of WEFM resulted in a significant inhibition of lung metastasis after intravenous injection of colon 26-L5 cells in a dose-dependent manner. There was also a significant increase in T cell and B cell mitogenic stimuli and production of IFN-g by splenocytes stimulated with Con A compared to untreated controls. Conclusion : WEFM may have anti-tumor activities via Th1-type dominant immune responses.

Keywords

References

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