Advances in Traditional Medicine

  • 제9권2호
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  • Pages.135-141
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  • 2009
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

  • Lee, Chang-Hwan (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Yoon, Byung-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-Industry, Daegu Haany University)
  • 발행 : 2009.06.30
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초록

The purpose of this study was to characterize the putative anxiolytic-like effects of the 70% ethanol extract of Portulaca oleracea (EPO) using an elevated plus maze (EPM) in mice. The EPO was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM, respectively. Control mice were treated with an equal volume of 10% tween 80, and positive control mice with diazepam (1 mg/kg). Single treatments of the EPO significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus controls (P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolytic-like effects of the EPO were blocked by flumazenil (10 mg/kg, i.p), a $GABA_A$ antagonist not by WAY 100635 (0.3 mg/kg, i.p), a 5-$HT_{1A}$ receptor antagonist. These results indicate that P. oleracea is an effective anxiolytic agent, and suggest that the anxiolytic-like effects of P. oleracea is mediated via the GABAergic nervous system.

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참고문헌

  1. Atack JR. (2003) Anxioselective compounds acting at the $GABA_A$ receptor benzodiazepine binding site. Curr. Drug. Targets. CNS. Neurol. Disord. 2, 213-232
  2. Awad NE. (1994) Lipid content and antimicrobial activity of phenolic constituents of cultivated Portulaca oleracea L., Bull. Faculty Pharm. Cairo Univ. 32, 137–142
  3. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. (1998) Subtypes of a-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50, 291-314
  4. Beaubrun G, Gray GE. (2000) A review of herbal medicines for psychiatric disorders. Psychiatr. Serv. 51, 1130-1134 https://doi.org/10.1176/appi.ps.51.9.1130
  5. Bonetti EP, Pieri L, Cumin R, Schaffner R, Pieri M, Gamzu ER, Muller RKM, Haefely W. (1982) Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects. Psychopharmacology 78, 8-18 https://doi.org/10.1007/BF00470579
  6. Carlini EA. (2003) Plants and the central nervous system. Pharmacol. Biochem. Behav. 75, 501-512 https://doi.org/10.1016/S0091-3057(03)00112-6
  7. Dawson GR, Tricklebank MD. (1995) Use of the elevated plus maze in the search for novel anxiolytic agents. Trends. Pharmacol. Sci. 16, 33-36 https://doi.org/10.1016/S0165-6147(00)88973-7
  8. Desai AK, Grossberg GT. (2003) Herbals and botanicals in geriatric psychiatry. Am. J. Geriatr. Psychiatry. 11, 498-506 https://doi.org/10.1097/00019442-200309000-00004
  9. Elkhayat ES, Ibrahim SR, Aziz MA. (2008) Portulene, a new diterpene from Portulaca oleracea L. J. Asian Nat. Prod. Res. 10, 1039-1043 https://doi.org/10.1080/10286020802320590
  10. Fugh-Berman A, Cott JM. (1999) Dietary supplements and natural products as psychotherapeutic agents. Psychosom. Med. 61, 712-728 https://doi.org/10.1097/00006842-199909000-00012
  11. Korpi ER, Grunder G, Luddens H. (2002) Drug interactions at GABA(A) receptors. Prog. Neurobiol. 67, 113-159 https://doi.org/10.1016/S0301-0082(02)00013-8
  12. Lader M, Morton S. (1991) Benzodiazepine problems. Br. J. Addict. 86, 823-828 https://doi.org/10.1111/j.1360-0443.1991.tb01831.x
  13. Lake J. (2000) Psychotropic medications from natural products: a review of promising research and recommendations. Altern, Ther. Health. Med. 6, 36-52
  14. Liao JF, Hung WY, Chen CF. (2003) Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur. J. Pharmacol. 464, 141-146 https://doi.org/10.1016/S0014-2999(03)01422-5
  15. Linde K, ter Riet G, Hondras M, Vickers A, Saller R, Melchart D. (2001) Systematic reviews of complementary therapies-an annotated bibliography. Part 2: herbal medicine. BMC. Complement. Altern. Med. 1, 5 https://doi.org/10.1186/1472-6882-1-5
  16. Linde K, Vickers A, Hondras M, ter Riet G, Thormahlen J, Berman B, Melchart D. (2001) Systematic reviews of complementary therapies-an annotated bibliography. Part 1: acupuncture. BMC. Complement. Altern. Med. 1, 3 https://doi.org/10.1186/1472-6882-1-3
  17. Liu L, Howe P, Zhou YF, Xu ZQ, Hocart C, Zhan R. (2000) Fatty acids and $\beta$-carotene in Australian purslane (Portulaca oleracea) varieties. Journal of Chromatography A 893, 207-213 https://doi.org/10.1016/S0021-9673(00)00747-0
  18. Mckernan RM, Whiting PJ. (1996) Which $GABA_A$receptor subtypes really occur in the brain? Trends Neurosci. 19, 139-143 https://doi.org/10.1016/S0166-2236(96)80023-3
  19. Medina JH, Viola H, Wolfman C, Marder M, Wasowski C, Calvo D, Paladini AC. (1997) Overview--flavonoids: a new family of benzodiazepine receptor ligands. Neurochem Res. 22, 419-425 https://doi.org/10.1023/A:1027303609517
  20. Radhakrishnan R, Zakaria MN, Islam MW, Chen HB, Kamil M, Chan K, Al-Attas A. (2001) Neuropharmacological actions of Portulaca oleraceae L v. sativa (Hawk). J Ethnopharmacol. 76, 171-176 https://doi.org/10.1016/S0378-8741(01)00230-6
  21. Sandford JJ, Argyropoulos SV, Nutt DJ. (2000) The psychobiology of anxiolytic drugs. Part 1: Basic neurobiology. Pharmacol Ther. 88, 197-212 https://doi.org/10.1016/S0163-7258(00)00082-6
  22. Sakai N, Inada K, Okamoto M, Shizuri Y, Fukuyama Y. (1996). Portuloside A, a monoterpene glucoside, from Portulaca oleracea. Phytochemistry. 42, 1625-1628 https://doi.org/10.1016/0031-9422(96)00202-6
  23. Stahl SM. (2002) Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder. J Clin. Psychiatry. 63, 756-757 https://doi.org/10.4088/JCP.v63n0901
  24. Walter G, Rey JM. (1999) Use of St. John's Wort by adolescents with a psychiatric disorder. J. Child. Adolesc. Psychopharmacol. 9, 307-311 https://doi.org/10.1089/cap.1999.9.307
  25. Wittchen HU, Hoyer J. (2001) Generalized anxiety disorder: nature and course. J Clin Psychiatry. 11, 15-19
  26. Xiang L, Xing D, Wang W, Wang R, Ding Y, Du L. (2005) Alkaloids from Portulaca oleracea L. Phytochemistry 66, 2595-2601 https://doi.org/10.1016/j.phytochem.2005.08.011
  27. Xu X, Yu L, Chen G. (2006) Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection. J Pharm Biomed Anal. 41, 493-499 https://doi.org/10.1016/j.jpba.2006.01.013

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