Advances in Traditional Medicine

  • 제9권2호
  • /
  • Pages.115-127
  • /
  • 2009
  • /
  • 2662-4052(pISSN)
  • /
  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
권호 표지
DOI QR코드

DOI QR Code

Samsoeum inhibits systemic anaphylaxis and release of histamine, cytokine in vivo and in vitro

  • Kim, Su-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Na-Hyung (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Moon, Phil-Dong (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Myung, Noh-Yil (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Min-Chol (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Lee, Ki-Taek (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Jo, Hyung-Mook (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Kim, Na-Hyun (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Rim, Hong-Kun (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Seo, Min-Jun (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Kim, Jin-Man (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Seung-Eun (College of Oriental Medicine, Wonkwang University) ;
  • An, Nyeon-Hyung (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University) ;
  • Lee, Kang-Min (Division of Biological Sciences, College of Natural Science, Chonbuk National University) ;
  • Lee, Si-Hyung (College of Oriental Medicine, Wonkwang University) ;
  • Park, Yun-Jum (Division of Horticulture and Pet Animal-Plang Science, Wonkwang University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University)
  • 발행 : 2009.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Samsoeum (SSE) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the SSE is still not fully understood. The aim of the present study is to elucidate whether and how SSE modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that SSE significantly decreased compound 48/80-induced systemic anaphylaxis, ear-swelling response, histamine release from preparation of rat peritoneal mast cells and anti-dinitropheny IgE-induced passive cutaneous reaction. Also, SSE inhibited the expression of inflammatory cytokine and cyclooxygenase-2 in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of SSE is through suppression of nuclear factor-${\kappa}B$ activation and $I{\kappa}B-{\alpha}$ phosphorylation/degradation in HMC-1. These results provided new insight into the pharmacological actions of SSE as a potential molecule for therapy of inflammatory allergic diseases.

키워드

참고문헌

  1. Artuc M, Hermes B, Steckelings UM, Grutzkau A, Henz BM. (1999) Mast cells and their mediators in cutaneous wound healing-active participants or innocent bystanders Exp. Dermatol. 8, 1-16 https://doi.org/10.1111/j.1600-0625.1999.tb00342.x
  2. Barnes PJ, Karin M. (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336, 1066-1071 https://doi.org/10.1056/NEJM199704103361506
  3. Beutler B. (1995) TNF, immunity and inflammatory disease: lessons of the past decade. J. Invest. Med. 43, 227-235
  4. Bochenek G, Nizankowska E, Gielicz A, Swierczynska M, Szczeklik A. (2004) Plasma 9alpha, 11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. Thorax. 59, 459-464 https://doi.org/10.1136/thx.2003.013573
  5. Choo MK, Park EK, Han MJ, Kim DH. (2003) Antiallergic activity of ginseng and its ginsenosides. Planta Med. 69, 518-522 https://doi.org/10.1055/s-2003-40653
  6. Galli SJ. (2000) Allergy. Curr. Biol. 10, 93-95 https://doi.org/10.1016/S0960-9822(00)00322-5
  7. Ghosh S, May MJ, Kopp EB. (1998) NF-$\kappa$B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260 https://doi.org/10.1146/annurev.immunol.16.1.225
  8. Gordon JR, Burd PR, Galli SJ. (1990) Mast cells as a source of multifunctional cytokines. Immunol. Today 11, 458-464 https://doi.org/10.1016/0167-5699(90)90176-A
  9. Hamelmann E, Tadeda K, Oshiba A, Gelfand EW. (1999) Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness. Allergy 54, 297-305 https://doi.org/10.1034/j.1398-9995.1999.00085.x
  10. Jeong HJ, Koo HN, Na HJ, Kim MS, Hong SH, Eom JW, Kim KS, Shin TY, Kim HM. (2002) Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine 18, 252-259 https://doi.org/10.1006/cyto.2002.0894
  11. Jippo-Kanemoto T, Kasugai T, Yamatodani A, Ushio H, Mochizuki T, Tohya K, Kimura M, Nishimura M, Kitamura Y. (1993) Supernormal histamine release and normal cytotoxic activity of beige (Chediak-Higashi syndrome) rat mast cells with giant granules. Int. Arch. Allergy Immunol. 100, 99-106 https://doi.org/10.1159/000236395
  12. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17, 2115-2117 https://doi.org/10.1096/fj.03-0329fje
  13. Kawata R, Reddy ST, Wolner B, Herschman HR. (1995) Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. J. Immunol. 155, 818-825
  14. Kim MS, Lim WK, Cha JG, An NH, Yoo SJ, Park JH, Kim HM, Lee YM. (2001) The activation of PI 3-K and PKC zeta in PMA-induceddifferentiation of HL-60 cells. Cancer Lett. 171, 79-85 https://doi.org/10.1016/S0304-3835(01)00505-5
  15. Kim SH, Choi YK, Jeong HJ, Kang HU, Moon G, Shin TY, Kim HM. (2000) Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpini oxyphylla in rats. Immunopharmacol. Immunotoxicol. 22, 267-277 https://doi.org/10.3109/08923970009016420
  16. Kim YP, Lee EB, Kim SY, Li D, Ban HS, Lim SS, Shin KH, Ohuchi K. (2001) Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Planta Med. 67, 362-364 https://doi.org/10.1055/s-2001-14317
  17. Kruger-Krasagakes S, Czarnetzki BM. (1995) Cytokine secretion by human mast cells. Exp. Dermatol. 4, 250-254 https://doi.org/10.1111/j.1600-0625.1995.tb00253.x
  18. Meade EA, Smith WL, DeWitt DL. (1993) Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages. J. Bio. Chem. 268, 6610-6614
  19. Medzhitov R, Janeway CA Jr. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298 https://doi.org/10.1016/S0092-8674(00)80412-2
  20. Metcalfe DD, Baram D, Mekori YA. (1997) Mast cells. Physiol. Rev. 77, 1033-1079 https://doi.org/10.1152/physrev.1997.77.4.1033
  21. Moon PD, Na HJ, Kim HM. (2003) Action of enzyme food, Green Life Enzyme of systemic and local anaphylaxis. Orient. Pharm. Exp. Med. 3, 46-50 https://doi.org/10.3742/OPEM.2003.3.1.046
  22. Mukaida N. (2000) Inerleukin-8: and expanding universe beyond neutrophil chemotaxis and activation. Int. J. Hematol. 72, 391-398
  23. Na HJ, Jeong HJ, Bae H, Kim YB, Park ST, Yun YG, Kim HM. (2002) Tongkyutang inhibits mast celldependent allergic reactions and inflammatory cytokines secretion. Clin. Chim. Acta 7, 35-41 https://doi.org/10.1016/S0009-8981(02)00011-6
  24. O'Sullivan S, Dahlen SE, Larsson K, Larsson BM, Malmberg P, Kumlin M, Palmberg L. (1998) Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. Thorax 53, 1041-1046 https://doi.org/10.1136/thx.53.12.1041
  25. Oguma T, Asano K, Shiomi T, Fukunaga K, Suzuki Y, Nakamura M, Matsubara H, Sheldon HK, Haley KJ, Lilly CM, Drazen JM, Yamaguchi K. (2002) Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs. Am. J. Respir. Crit. Care Med. 165, 382-386 https://doi.org/10.1164/ajrccm.165.3.2103093
  26. Petersen LJ, Mosbech H, Skov PS. (1996) Allergeninduced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol. 97, 672-679 https://doi.org/10.1016/S0091-6749(96)70313-5
  27. Schaecher K, Goust JM, Banik NL. (2004) The effects of calpain inhibition on I$\kappa$B alpha degradation after activation of PBMCs: identification of the calpain cleavage sites. Neurochem. Res. 29, 1443-1451 https://doi.org/10.1023/B:NERE.0000026410.56000.dd
  28. Schoonbroodt S, Legrand-Poels S, Best-Belpomme M, Piette J. (1997) Activation of the NF-$\kappa$B transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem. J. 321, 777-775 https://doi.org/10.1042/bj3210777
  29. Shore PA, Burkhalter A, Cohn VH. (1959) A method for fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127, 182-186
  30. Tasaka K, Mio M, Okamoto M. (1986) Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy 56, 464-469
  31. Walsh LJ, Davis MF, Xu LJ, Savage NW. (1995) Relationship between mast cell degranulation, release of TNF, and inflammation in the oral cavity. J. Oral Pathol. Med. 26, 266-272 https://doi.org/10.1111/j.1600-0714.1995.tb01180.x
  32. Wang CC, Chen LG, Lee LT, Yang LL. (2003) Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In Vivo 17, 641-645
  33. Wershil BK, Merkori YA, Murakami T, Galli SJ. (1987) 125I-fibrin deposition in IgE dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast celldeficient mice locally reconstituted with cultured mast cells. J. Immunol. 139, 2605-2614
  34. Yamamoto Y, Yin MJ, Lin KM, Gaynor RB. (1999) Sulindac inhibits activation of the NF-kappaB pathway. J. Biochem. 274, 27307-27314
  35. Yu SC, Li XY. (2000) Effect of ginsenoside on IL-1 beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. Acta Pharmacol. Sin. 21, 915-918
  36. Yurt RW, Leid RW, Austen KF. (1997) Native heparin from rat peritoneal mast cells. J.Biol. Chem. 252, 518-521

피인용 문헌

  1. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK1/2 in 3T3-L1 Cells vol.2015, pp.1741-4288, 2015, https://doi.org/10.1155/2015/893934