Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Study on Kidney Toxicities of WK-38 for Treatment Vascular Diseases in Rats

혈관질환 억제 효능이 있는 WK-38의 백서 신장 독성연구

  • Kim, Eun-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, An-Sook (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Shin, Sun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Sung-Yeon (Dept. of Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Chang, Bo-Yoon (Dept. of Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김은주 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이안숙 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 신선 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김성연 (원광대학교 약학대학 약학과) ;
  • 장보윤 (원광대학교 약학대학 약학과) ;
  • 이호섭 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 강대길 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2009.12.30
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Abstract

The kidney toxicities of WK-38 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with WK-38, no mortality and gross pathological findings were shown for 13 weeks. There was substantially no change in body weight in all rats with treatment of WK-38. Urine osmolality as renal functional parameters were not exchanged in all rats treated with WK-38. The renal functional parameters including electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were significantly augmented on account of increase in urinary volume in female rats treated with WK-38, but not male. In summary, this study demonstrates that WK-38 exhibits no toxicity on kidney in all male and female rats.

Keywords

References

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