대한한의학방제학회지 (Herbal Formula Science)

  • 제17권2호
  • /
  • Pages.111-121
  • /
  • 2009
  • /
  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

한약재 추출물 함유 앰플의 주름개선 효능에 관한 기초 임상연구

The Efficacy of Ampule Containing Herbal Extract for Improving Skin Wrinkles in Women

  • 도은주 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 이진상 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 박현진 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 하일도 (대구한의대학교 제한동의학술원) ;
  • 김영철 (계명대학교 자연과학대학 공중보건학과) ;
  • 김미려 ((재)테크노파크 한방산업지원센터 임상시험지원팀)
  • Do, Eun-Ju (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Lee, Jin-Sang (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Park, Hyun-Jin (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Ha, Il-Do (Jeahan Oriental Medical Academy, Daegu Haany University) ;
  • Kim, Young-Chul (Department of Public Health, College of Natural Sciences, Keimyung University) ;
  • Kim, Mi-Ryeo (Clinical Research Support Team, Oriental Medicine, Industry Support Center)
  • 발행 : 2009.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : This study was performed to evaluate the efficacy of ampule containing herbal extract(Ulmus davidiana, Ginkgo biloba, Perilla ocymoides, Morus alba, Glycyrrhiza uralensis (licorice), and Angelica gigas) on skin wrinkles in adult women with facial wrinkles. Methods : A total of 12 women, 30 to 46 years of age, with wrinkles in the corner of eyes, applied ampule containing herbal extract twice daily for up to 12 weeks. Silicon replicas of right crow's feet area and antecubital fossa were taken before use of test product and at 4, 8 and 12 weeks. The replicas were analyzed by optical profilometry with Skin Visiometer SV600. The wrinkle and roughness parameters, R1, R2, R3, R4 and R5 were calculated and statistically analyzed. In addition, a subjective evaluation of product efficacy was conducted by patient's assessment. Results : The mean values of all the skin roughness parameters were decreased at 4-week, and decreased significantly at 8 and 12-week except R4 at 12-week after test product use. The subjective evaluation of wrinkle by patient's assessment was also improved. However, one patient noted stiffness of face after use of test product. Conclusions : These study suggested that the application of ampule containing herbal extract twice daily for 12 weeks may effectively improve the facial wrinkles without severe side effect.

키워드

참고문헌

  1. 강금석, 김인덕, 권륜희, 허예영, 오상훈, 김민아, 정혜진, 강환열, 하배진. 한방 원료 추출물의 주름개선 효과를 통한 화장품 원로로서의 가치 평가. Journal of Life Science. 2007:17:1147-51. https://doi.org/10.5352/JLS.2007.17.8.1147
  2. 이영훈, 최우식, 박기훈, 최영주, 길상환. 포도와 오이즙액을 이용한 동충하초(Paecilomyces japonica) 균사체 배양액의 피부 주름개선효과. Journal of Life Science. 2006:16:516-21. https://doi.org/10.5352/JLS.2006.16.3.516
  3. Collier A. Wilson R. Bradley H. Thomson, JA. Small ::VI. Free radical activity in type 2 diabetes. Diabetic Medicine. 1990:7:27-31. https://doi.org/10.1111/j.1464-5491.1990.tb01302.x
  4. Jeung YA. Bae JH. Evaluation of biological activities on the extractives of pinaceae. J. Soc. Cos. Sci. Kor. 2005;31;121-5.
  5. Tolmasoff JM. Ono T. Culture RG. Supcroxidc dismutase correlation with life-span and specific methanolic rate in promate species. Proc. Natl. Sci. USA. 1980;77:2777-81. https://doi.org/10.1073/pnas.77.5.2777
  6. Kang HH. Anti-aging in cosmetics. J. Soc. Cos. Sci. Kor. 1997; 23: 07-61.
  7. Shao LX, Effects of the extract from bergamot and boxthorn on the delay of skin aging and hair growth in mice. Zhongguo Zhong Yao Za Zhi. 2003:28: 766-72.
  8. Doris EB, Cosmetics for elderly people. Cosmetics and Toilctorics, 2006;111:31-7.
  9. West MD, The Cellular and Molecular Biology of Skin Aging. Arch Dermatol. 1994;130:87-95. https://doi.org/10.1001/archderm.1994.01690010091014
  10. Uitto J. Connective tissue biochemistry of the aging dermis: Age-related alterations in collagen and elastin. Dermatol. Clin. 1986:4:433-46.
  11. Kim MJ, Kim JY, Choi SW. Hong JT, Yoon KS. Anti-wrinkle effect of Safflower ( Cetluunu: tioctorins) seed extract. J. Soc. Cos. Sci. Kor. 2004; :30: 15-22.
  12. Garrcl C, Fontccavc M. Nitric Oxide. Chemistry and biology analysis of free radicals in biological systems. 1995;21-35.
  13. Hogg N. Pro-oxidant and antioxidant effects of nitric oxide. Analysis of Free Radicals in Biological Systems. 1995:37-49.
  14. Rice Evans CA. Formation of free radicals and mechanisms of action in normal biochemical processes and pathological states. in Free Radical Damage and Its Control. Elsevier. 1994:131-53.
  15. Gilchrest BA. Skin aging and photoaging an overview. J. Am. Acad. Derm, 1989;21 :610-3. https://doi.org/10.1016/S0190-9622(89)70227-9
  16. Kim SJ. Kwcon DB. Lee JH. Investigation of antioxidative activity and stability of ethanol extracts of licorice root (Glycyrrhiza glsbtn). Korean J. Food Sci. Tcchnol. 2006:38:584-8.
  17. Woo KS. Hwang IG. Noh YH. Jeong HS. Antioxidant activity of heated licorice (Glycyrrhiza uralensis fisch) extracts in korea. J Korean Soc Food Sci Nutr. 2007:36(6):689-95. https://doi.org/10.3746/jkfn.2007.36.6.689
  18. Song JC. Park NK. Hur HS. Bang MH, Baek NI. Examination and isolation of natural antioxidants from korean medicinal plants. Korean. J. Medicinal Crop Sci. 2009:8(2):94-101.
  19. Jee SO, Antioxidant a ctivities and whitening effect of the mulberry (Morus alba L.) root bark extracts. Korean J. Plant Res. 2009:22(2) : 145-51.
  20. Kim MH, Kang WW. Lee NH. K woen DJ. Choi UK. Antioxidant activities of extract with water and ethanol of perilla tnnescens var. acuta kudo leaf. J. Korean Soc. Appl. Biol. Chem. 2007:50(4) :327-33.
  21. Kim CH. Kwon MC. Han JG. Na CS. Kwak HG, Choi GP. Park UY. Lee HY. Skinwhitening and UV-protective effects of Angelica gjgas nakai extracts on ultra high pressure extraction process, Korean J. Medicinal Crap Sci. 2008;16: 255-60.
  22. Kang SS, Kim JS. Kwak WJ. Kim KH. Flavonoids from the leaves of Ginkgo bilobs. Kor, J. Pharmacogn. 1990;21(2):111-20.
  23. Song EY. Song MK, Dycability and UV-blocking effect of dyed fabrics with ginkgo extract. Korean J. Community Living Science. 2007:18(3):391-8.
  24. 주식회사 태평양. 피부탄력 증진용 화장료 조성물. 대한민국특허청 공개특허공보. 2004:10 2004-0034837.
  25. (주)더페이스양코리아. 생약추출 혼합물 함유하는 피부 노화 방지용 화장료조성물. 대한 민국특허청 등록특허공보 2006:10-2006-0086250.
  26. (주)더페이스샵코리아. 나노리포좀으로 안정화된 생약추출 혼합물을 함유하는 피부노화 방지용 화장료 조성물. 2006-10-2006-0119583.
  27. Kim YC et. al., Inhibitory effects of oriental herbal extracts on skin wrinkle formation in hairless mice. in preparation.