The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Saengkankeonbi-tang on Prevention of Hyperlipidemia and Liver Damage Induced by Alcohol

생간건비탕(生肝健脾湯)이 알코올 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향

  • Hwang, Soo-Jin (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Choi, Hong-Sik (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Kim, Seung-Mo (Department of Oriental Internal Medicine, Daegu Haany University) ;
  • Woo, Chang-Hoon (Department of Oriental Rehabilitation Medicine, Daegu Haany University)
  • 황수진 (대구한의대학교 한의학과 간계내과학교실) ;
  • 최홍식 (대구한의대학교 한의학과 간계내과학교실) ;
  • 김승모 (대구한의대학교 한의학과 간계내과학교실) ;
  • 우창훈 (대구한의대학교 한의학과 한방재활의학과교실)
  • Published : 2009.12.30
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Abstract

Objectives : This study was performed to investigate the effect of water extracts from Saengkankeonbi-tang on prevention of hyperlipidemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rats the control and Saengkankeonbi-tang groups with 25% alcohol for 55 days. For the same period we fed the Saengkankeonbi-tang group with Saengkankeonbi-tang extract as well and rats in normal and contrlo group on saline solution. We measured the serum components in rat's blood, body weight and weight of liver. Results : 1. At first, we observed effects of Saengkankeonbi-tang on prevention of hyperlipemia induced by alcohol. Saengkankeonbi-tang group showed significant decrease in total cholesterol levels in comparison with those of the control group. Saengkankeonbi-tang group showed significant increase in HDL-cholesterol levels in comparison with those of the control group. Saengkankeonbi-tang group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. 2. At second, we observed effects of Saengkankeonbi-tang on prevention of liver damage induced by alcohol. Saengkankeonbi-tang group showed significant decrease in GOT, GPT, LDH and ALP levels in comparison with those of the control group. Saengkankeonbi-tang group showed significant increase of liver weight in comparison with those of the control group. Conclusions : Reviewing these experimental results, it appears that water extracts from Saengkankeonbi-tang have pharmaceutical efficacy on prevention of hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.

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References

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