Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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CLINICAL STUDY OF ODONTOGENIC KERATOCYST

치성 각화낭종의 임상적 연구

  • Seong, Hwa-Sik (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Lee, Ju-Min (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Hwang, Dae-Seok (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Yong-Deok (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Uk-Kyu (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Jong-Ryoul (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Chung, In-Kyo (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Shin, Sang-Hun (Dept. of Oral and maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 성화식 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 이주민 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 황대석 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김용덕 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김욱규 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김종렬 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 정인교 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Published : 2009.04.30
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Abstract

Purpose: The purpose of this study is to investigate the clinical and histological features of odontogenic keratocyst Patients and Methods: A retrosective review of 100 patients who were diagnosed as odontogenic keratocyst by hitological findings during the period of January 2000 and December 2005 in the Dept. of Oral and Maxillofacial surgery Pusan National University was consecuted. For each patient, age, sex, location of lesion, initial diagnosis by radiographic features, treatment procedure, hitologic findings and recurrance rate were evaluated. Results: In this study, OKC has male prevalance to female by 1.38:1, and most likely occurs during third decade. The most common site of lesion was mandibular ramus region(34.6%) and the most common symptom was swelling(50%). The most common initial diagnosis by radiographic findings was OKC and cyst enucleation was the most common treatment method. The recurrance rate was 28% and existence of daugther cyst is thought to be most convincing factor for prediction of recurrence. Conclusion: In this study, total recurrence rate was 28% and existence of daugther cyst is thought to be most convincing factor for prediction of recurrence. But, since 97% of patients were treated by enucleation and adjuntive excision, further styudy is need about concordance of recurrence rate with surgical method.

Keywords

References

  1. Sung-Hoon Chung, Eui-Wung Lee : A clinical and histopathologic study of benign odontogenic tumors. J Kor Oral Maxillofac Surg 1991;17:83-88
  2. Sang-kweon Cha, Il-Kyu Kim. Seong-Seob Oh : Clinical study of cyst in the jaw. J Kor Oral Maxillofac Surg 2001; 27:167-173
  3. J. Philip Sapp, Lewis R. Eversole, George P. Wysocki : Cysts of the oral regions in Contemporary oral and maxillofacial pathology. St. Louis. Mosby 1997
  4. Bataineh AB, al Qudah M : Treatment of mandibular odontogenic keratocysts : Oral Surg Oral Med Oral Pathol Oral Radiol 1998;86:42-49 https://doi.org/10.1016/S1079-2104(98)90148-2
  5. Voorsmit RA, Stoelinga PJ, van Haelst UJ : The management of keratocysts. J Maxillofac Surg 1981;9:228-233 https://doi.org/10.1016/S0301-0503(81)80049-5
  6. Payne TF. : An analysis of the clinical and histologic parameters of OKC. Oral Surg Oral Pathol 1972;33:536-46 https://doi.org/10.1016/0030-4220(72)90366-0
  7. Hodgkinson DJ. : Keratocysts of the jaw: clinicopathologic study of 79 patients. Cancer 1978;41:803-13 https://doi.org/10.1002/1097-0142(197803)41:3<803::AID-CNCR2820410304>3.0.CO;2-M
  8. Radden BG, Reade PC : Odontogenic keratocysts. Pathology 1973;5:525-534
  9. Minic AJ. : Primary intraosseous s1uamous cell carcinoma arising in a mandibrlar keratocyst. Int J Oral Maxillofac Surg 1992;21:163-165 https://doi.org/10.1016/S0901-5027(05)80786-6
  10. Stoelinga PJW, Bronkhorst FB. : The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg 1988;16:185-95 https://doi.org/10.1016/S1010-5182(88)80044-1
  11. Muller S, Waldron CA. : Primary intraosseous squamous carcinoma: report of two cases. Int J Oral Maxillofac Surg 1991;10:362-365 https://doi.org/10.1016/S0901-5027(05)80267-X
  12. Ahlfors E, Larsson A, Sjogren S. : The odontogenic keratocyst : a benign cystic tumor? J Oral Maxillofac Surg 1984;42:10-19 https://doi.org/10.1016/0278-2391(84)90390-2
  13. Shear M. : Cyst of the oral regions. 2nd ed. Bristol, England. Wright PSG. 1983
  14. Gustafson G, Lindahl B, Dahl E, Svensson A. : The nevoid basal cell carcinoma syndrome-Gorlin's syndrome. Multiple jaw cysts and skin cancer. Swed Dent J 1989;13:131-139
  15. Browne RM. : The odontogenic keratocysts: clinical aspects. Br Dent J 1970;128:225-231 https://doi.org/10.1038/sj.bdj.4802449
  16. Kakarantza-Angelopoulou E, Nicolatou O. : Odontogenic keratocysts: clinicopathologic study of 87 cases. J Oral Maxillofac surg 1990;48:593-599 https://doi.org/10.1016/S0278-2391(10)80472-0
  17. Brannon RB. : The odontogenic keratocyst: a clinicopathologic study of 312 cases. Part II: Histologic features. Oral Surg Oral Med Oral Pathol 1977;43:223-254 https://doi.org/10.1016/0030-4220(77)90161-X
  18. Chow HT. : Odontogenic keratocyst: a clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:573-577 https://doi.org/10.1016/S1079-2104(98)90348-1
  19. Kondell PA, Wiberg J. : Odontogenic keratocysts. A follow-up study of 29 cases. Swed Dent J 1988;12:57-62
  20. Vedtofte P, Praetorius F. : Recurrence of the odontogenic keratocysts in relation to clinical and histological features: a 20year follow- up study of 72 patients. Int J Oral Surg 1979;8:412-420 https://doi.org/10.1016/S0300-9785(79)80079-4
  21. Panders AK, Haddlers HN. : Solitary keratocysts of the jaws. J Oral Surg 1969;27:931-938
  22. Magnusson BC. : Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry. J Oral pathol 1978;7:8-18 https://doi.org/10.1111/j.1600-0714.1978.tb01880.x
  23. Keith DA. : Macroscopic satellite cyst formation in the odontogenic keratocyst. Report of two cases. Oral Surg Oral Med Oral Pathol 1973;35:21-27 https://doi.org/10.1016/0030-4220(73)90089-3
  24. Regezi JA, Sciubba JJ. Cysts of the oral region In: Regezi JA, Sciuba JJ, editors. Oral pathology: clinical-pathologic correlations. Philadelphia: WB Saunders; 1989
  25. Zachariades N, Papanicolaou S, Triantafyllou D. : Odontogenic keratocysts: review of the literature and report of sixteen cases. J Oral Maxillofac Surg 1985;43:177-182 https://doi.org/10.1016/0278-2391(85)90156-9
  26. Hjorting-Hansen E, Andreasen JO, Robinson LH. : A study of odontogenic cysts, with special reference to location of keratocysts. Br J Oral Surg 1969;7:15-23 https://doi.org/10.1016/S0007-117X(69)80056-9
  27. Emerson TG, Whitlock RI, Jones JH. : Involvement of soft tissue by odontogenic keratocysts (primordial cysts). Br J Oral Surg 1972;9:181-185 https://doi.org/10.1016/S0007-117X(71)80032-X
  28. Jackson It, Potparic Z, Fasching M, Schievink WI, Tidstrom K, Hussian K. : Penetration of the skull base by dissecting keratocyst. J Craniomaxillofac Surg 1993;21:319-325 https://doi.org/10.1016/S1010-5182(05)80490-1
  29. Chuong R, Donoff RB, Guralnick W. : The odontogenic keratocyst. J Oral Maxillofac Surg 1982;40:797-802 https://doi.org/10.1016/0278-2391(82)90177-X
  30. Donoff RB, Guralnick WC, Clayman L. : Keratocysts of the jaws. J Oral Surg 1972;30:880-884
  31. Harris M. : Odontogenic cyst growth and prostaglandin-induced bone resorption. Ann R Coll Surg Engl 1978;60:85-91
  32. Williams TP, Connor FA Jr. : Surgical management of the odontogenic keratocyst: aggressive approach. J Oral Maxillofac Surg 1994;52:964-966 https://doi.org/10.1016/S0278-2391(10)80081-3
  33. Anand VK, Arrowod JP, Krolls SO. : Malignant potential of the odontogenic keratocyst. Otolaryngol Head Neck Surg 1994;111:124-129 https://doi.org/10.1177/019459989411100122
  34. Forssel K. : The primordial cyst, a clinical and radiographic study. Proc Finn Dent Soc 1980;76:129-135
  35. Partridge M, Towers JF. : The primordial cyst (odontogenic keratocyst): its umour-like characteristics and behaviour. Br J Oral Maxillofac Surg 1987;25:271-279 https://doi.org/10.1016/0266-4356(87)90065-9
  36. Waldron CA. Odotogenic cyst and tumors. In: Neville BW, Damm DD, Allen CM, Bouquot JE, editors. Oral and maxillofacial pathology. Philadelphia: WB Saunders;1995.p.499-500
  37. Larsen PE, Hegtvedt AK. : Odontogenesis and odontogenic cysts and tumors. In: Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Schuller DE, editors. Otolaryngology-head and neck surgery. 2nd ed. St. Louis: Mosby; 1993.p.1427-1428
  38. Irvine GH, Bowerman JE. : Madibular keratocysts: surgical management. Br J Oral Maxillofac Surg 1985;23:204-209 https://doi.org/10.1016/0266-4356(85)90091-9
  39. Eyre J, Zakrzewska JM. : The conservative management of large odontogenic keratocysts. Br J Oral Maxillofac Surg 1985;23:195-203 https://doi.org/10.1016/0266-4356(85)90090-7
  40. Meara JG, Li KK, Shah SS, Cunningham MJ. : Odontogenic keratocysts in the pediatric population. Arch Otolaryngol Head Neck Surg 1996;122:725-728 https://doi.org/10.1001/archotol.1996.01890190021006
  41. Neville BW, Damm DD, Brock T. : Odontogenic Keratocysts of the midline maxillary region. J Oral Maxillofac Surg 1997;55:340-344 https://doi.org/10.1016/S0278-2391(97)90121-X