OVERALL FIVE-YEAR SURVIVAL RATE IN SQUAMOUS CELL CARCINOMA OF ORAL CAVITY

한국인에서 구강 편평세포암종의 5년 생존율

  • Oh, Min-Seok (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Kang, Sang-Hoon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Kim, Hyung-Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Zhenglin, Zhao (Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Ryu, Jae-In (Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Nam, Woong (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Cha, In-Ho (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
  • 오민석 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 강상훈 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김형준 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 조정림 (연세대학교 치과대학 구강종양연구소) ;
  • 류재인 (연세대학교 치과대학 구강종양연구소) ;
  • 남웅 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실)
  • Published : 2009.04.30

Abstract

The purpose of this epidemiologic study was to provide clinically useful information on the fundamentals for both the diagnosis and treatment planning of oral squamous cell carcinoma, which comprises $80{\sim}90%$ of all oral cancers. One hundred and forty two patients diagnosed with oral squamous cell carcinoma were selected from a total of 220 patients with oral malignancies. The patients' medical and follow-up records were reviewed and their survival was traced. The highest occurrence rate was observed in those aged between 60 and 69 years. The tongue was the most common primary site(31.7%) for oral squamous cell carcinoma. The survival rate was calculated using the Kaplan-Meier method. The overall five-year survival rate of oral squamous cell carcinoma patients was 66.90%. The 5-year survival rate according to stage was 85.82% for stage I, and 49.98% for stage IV. The five-year survival rate according to the originating site was 91.67% for the retromolar trigone, 75.30% for the tongue, and 62.41% for the maxillary gingiva. In terms of cell differentiation, the majority(58.5%) was the well-differentiated type, which had a 5-year survival rate of 70.62%.

Keywords

References

  1. Kujan O, Glenny AM, Duxbury J, Thakker N, Sloan P. Evaluation of screening strategies for improving oral cancer mortality: a Cochrane systematic review. J Dent Educ 2005 Feb;69(2):255-65
  2. Lo Muzio L, Santarelli A, Panzarella V, Campisi G, Carella M, Ciavarella D, et al. Oral squamous cell carcinoma and biological markers: an update on the molecules mainly involved in oral carcinogenesis. Minerva Stomatol 2007 Jun;56(6):341-7
  3. Klug C, Berzaczy D, Voracek M, Millesi W. Preoperative chemoradiotherapy in the management of oral cancer: a review. J Craniomaxillofac Surg 2008 Mar;36(2):75-88 https://doi.org/10.1016/j.jcms.2007.06.007
  4. Varela-Centelles PI, Seoane J, Vazquez Fernandez E, De La Cruz A, Garcia Asenjo JA. Survival to oral cancer. A study of clinical risk markers with independent prognostic value. Bull Group IntRech Sci Stomatol Odontol 2002 May-Sep;44(2):46-51
  5. Howaldt HP, Kainz M, Euler B, Vorast H. Proposal for modification of the TNM staging classification for cancer of the oral cavity. DOSAK. J Craniomaxillofac Surg 1999 Oct;27(5):275-88 https://doi.org/10.1054/jcms.1999.0070
  6. Robbins KT, Clayman G, Levine PA, Medina J, Sessions R, Shaha A, et al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg 2002 Jul;128(7):751-8 https://doi.org/10.1001/archotol.128.7.751
  7. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med 2008 Jan;37(1):1-10 https://doi.org/10.1111/j.1600-0714.2007.00579.x
  8. Krolls SO, Hoffman S. Squamous cell carcinoma of the oral soft tissues: a statistical analysis of 14,253 cases by age, sex and race of patients. J Am Dent Assoc 1976 Mar;92(3):571-4 https://doi.org/10.14219/jada.archive.1976.0556
  9. Chen J, Katz RV, Krutchkoff DJ. Intraoral squamous cell carcinoma. Epidemiologic patterns in Conneticut from 1935 to 1985. Cancer 1990 Sep;66(6):1288-96 https://doi.org/10.1002/1097-0142(19900915)66:6<1288::AID-CNCR2820660632>3.0.CO;2-N
  10. Blot W, McLaughlin JK, Winn DM. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988;8:3282- 3287
  11. Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous cell carcinoma of the oral cavity. Cancer 1990;6:109-113 https://doi.org/10.1002/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A
  12. Wu PC, Pang SW, Chan KW, Lai CL. Statistical and pathological analysis of oral tumors in the Hong Kong Chinese. J Oral Pathol 1986 Feb;15(2):98-102 https://doi.org/10.1111/j.1600-0714.1986.tb00585.x
  13. Leite ICG, Koifman S. Survival analysis in a sample of oral cancer patients at a reference hospital in Rio de Janeiro, Brazil. Oral Oncol 1998;4:347-352 https://doi.org/10.1016/S1368-8375(98)00019-0
  14. Johnson N. Tobacco use and oral cancer: a global perspective. J Dent Educ 2001 Apr;65(4):328-39
  15. Maier H, Zeller J, Hermann A, et al. Dental status and oral hygiene in patients with head and neck cancer otolaryngology. Head Neck Surg 1993;08:655-61 https://doi.org/10.1177/019459989310800606
  16. Gonzalez-Garcia R, Naval-Gias L, Rodriguez-Campo FJ, Sastre-Perez J, Munoz-Guerra MF, Gil-Diez Usandizaga JL. Contralateral lymph neck node metastasis of squamous cell carcinoma of the oral cavity: a retrospective analytic study in 315 patients. J Oral Maxillofac Surg 2008 Jul;66(7):1390-8 https://doi.org/10.1016/j.joms.2008.01.012
  17. Inagi K, Takahashi H, Okamoto M, et al. Treatment effects in patients with squamous cell carcinoma of the oral cavity. Acta Otolaryngol Suppl 2002;47:25-9 https://doi.org/10.1080/000164802760057527
  18. Casiglia J, Woo SB. A comprehensive review of oral cancer. Gen Dent 2001 Jan-Feb;49(1):72-82