Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antimicrobial Agent from Schima wallichii ssp. liukiuensis against Candida spp.

Schima wallichii ssp. Liukiuensis 추출물 Sterol Glycoside의 Candida spp.에 대한 항균활성

  • Shin, Kuem (Division of Research Planning and Coordination, Korea Forest Research Institute) ;
  • Min, Ji-Yun (Division of Environmental Forest Science, Gyeongsang National Univ.) ;
  • Kang, Seung-Mi (Division of Forest Research, Gyeongsangnam-do Forest Envirionmental Institude) ;
  • Park, Dong-Jin (Division of Environmental Forest Science, Gyeongsang National Univ.) ;
  • Song, Hyun-Jin (Division of Environmental Forest Science, Gyeongsang National Univ.) ;
  • Kwon, Oh-Woong (Division of Research Planning and Coordination, Korea Forest Research Institute) ;
  • Yang, Jae-Kyung (Division of Environmental Forest Science, Gyeongsang National Univ.) ;
  • Karigar, Chandrakant S. (Department of Biochemistry, Bangalore University) ;
  • Choi, Myung-Suk (Division of Environmental Forest Science, Gyeongsang National Univ.)
  • 신금 (국립산림과학원) ;
  • 민지윤 (경상대학교 환경산림과학부(경상대학교 농업생명과학 연구원)) ;
  • 강승미 (경상남도 산림환경연구원) ;
  • 박동진 (경상대학교 환경산림과학부(경상대학교 농업생명과학 연구원)) ;
  • 송현진 (경상대학교 환경산림과학부(경상대학교 농업생명과학 연구원)) ;
  • 권오웅 (국립산림과학원) ;
  • 양재경 (경상대학교 환경산림과학부(경상대학교 농업생명과학 연구원)) ;
  • ;
  • 최명석 (경상대학교 환경산림과학부(경상대학교 농업생명과학 연구원))
  • Published : 2009.02.28
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Abstract

This study carried out development of a natural antimicrobial agent from Schima wallichii ssp. liukiuensis. Compound I exhibiting potent antimicrobial activity against Candida spp. was isolated from the methanol extracts of Schima wallichii ssp. liukiuensis. The structure of I identified as a sterol glycoside consisted of a trisaccharide and ${\alpha}_1$-sitosterol. Trisaccharide composed of L-rhamnose, D-galactose and D-glucose residues. The antimicrobial activity of I was selective on yeast rather than bacteria or other fungi. Compound I was demonstrated to be ineffective against toxicity to mouse liver cells where as protective to human dermal fibroblast cells at low concentrations. Thus, it is reasonable to expect a sterol glycoside (I) as a valuable alternative for synthetic antifungal.

Keywords

References

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