Journal of Cardiovascular Imaging

Korean Society of Echocardiography (한국심초음파학회)
권호 표지
DOI QR코드

DOI QR Code

RELATIONSHIP BETWEEN THE ECHOCARDIOGRAPHIC EPICARDIAL ADIPOSE TISSUE THICKNESS AND SERUM ADIPONECTIN IN PATIENTS WITH ANGINA

  • Yun, Kyeong-Ho (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Rhee, Sang-Jae (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Yoo, Nam-Jin (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Oh, Seok-Kyu (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Kim, Nam-Ho (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Jeong, Jin-Won (Department of Cardiovascular Medicine, Wonkwang University Hospital) ;
  • Park, Do-Sim (Institute of Wonkwang Medical Science, Wonkwang University College of Medicine) ;
  • Park, Hyun-Young (Institute of Wonkwang Medical Science, Wonkwang University College of Medicine)
  • Published : 2009.12.27
⟨ Previous Next ⟩

Abstract

Background: It is still unknown whether increased cardiac adiposity is related to the risk factors of coronary artery disease (CAD). We measured epicaridal adopose tissue (EAT) and mediastinal adipose tissue (MAT) using echocardiography and examined their correlations with CAD and serum adiponectin. Methods: One hundred fifty three patients who underwent elective coronary angiography for chest pain were measured cardiac adiposity by transthoracic echocardiography. The correlations of cardiac adipose tissue with the presence and severity of CAD and the serum adiponectin level were examined. Results: EAT was thicker in patients with CAD (1.8${\pm}$1.4 vs. 3.8${\pm}$1.9 mm, p<0.001), but MAT was not different according to the presence of CAD (2.9${\pm}$2.8 vs. 3.5${\pm}$2.5 mm, p=0.121). EAT showed a significant positive correlation with age (r=0.225, p=0.005), homocystein (r=0.289, p=0.001), fasting glucose (r=0.167, p=0.042), and fibrinogen (r=0.218, p=0.009), and a significant negative correlation with serum adiponectin (r=-0.194, p=0.016). EAT thickness (OR 11.53, 95% CI; 3.61-36.84, p<0.001) and low serum adiponectin (OR 2.88, 95% CI; 1.02-8.15, p=0.046) were independent predictors of obstructive CAD. However, MAT thickness was not associated with CAD. Conclusion: EAT was associated with the severity and risk factors of CAD and correlated with serum adiponectin level. In contrast with EAT, MAT was not associated with CAD and adiponectin.

Keywords

References

  1. Gorter PM, de Vos AM, van der Graaf Y, Stella PR, Doevendans PA, Meijs MF, Prokop M, Visseren FL. Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography. Am J Cardiol 2008;102:380-5. https://doi.org/10.1016/j.amjcard.2008.04.002
  2. Ahn SG, Lim HS, Joe DY, Kang SJ, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH. Relationship of epicardial adipose tissue by echocardiography to coronary artery disease. Heart 2008;94:e7. https://doi.org/10.1136/hrt.2007.118471
  3. Eroglu S, Sade LE, Yildirir A, Bal U, Ozbicer S, Ozgul AS, Bozbas H, Aydinalp A, Muderrisoglu H. Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease. Nutr Metab Cardiovasc Dis 2009;19:211-7. https://doi.org/10.1016/j.numecd.2008.05.002
  4. Sarin S, Wenger C, Marwaha A, Qureshi A, Go BD, Woomert CA, Clark K, Nassef LA, Shirani J. Clinical significance of epicardial fat measured using cardiac multislice computed tomography. Am J Cardiol 2008;102:767-71. https://doi.org/10.1016/j.amjcard.2008.04.058
  5. Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, Rhee SJ, Lee EM, Lee J, Yoo NJ, Kim NH, Park JC. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J 2007;71:536-9. https://doi.org/10.1253/circj.71.536
  6. Djaberi R, Schuijf JD, van Werkhoven JM, Nucifora G, Jukema JW, Bax JJ. Relation of epicardial adipose tissue to coronary atherosclerosis. Am J Cardiol 2008;102:1602-7. https://doi.org/10.1016/j.amjcard.2008.08.010
  7. Hwang JW, Choi UJ, Ahn SG, Lim HS, Kang SJ, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH, Kang DK. Echocardiographic plains reflecting total amount of epicardial adipose tissue as risk factor of coronary artery disease. J Cardiovasc Ultrasound 2008;16:17-22. https://doi.org/10.4250/jcu.2008.16.1.17
  8. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108:2460-6. https://doi.org/10.1161/01.CIR.0000099542.57313.C5
  9. Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, Gallo P, di Gioia CR. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 2005;29:251-5.
  10. Iacobellis G, di Gioia CR, Cotesta D, Petramala L, Travaglini C, De Santis V, Vitale D, Tritapepe L, Letizia C. Epicardial adipose tissue adiponectin expression is related to intracoronary adiponectin levels. Horm Metab Res 2009;41:227-31. https://doi.org/10.1055/s-0028-1100412
  11. Sironi AM, Gastaldelli A, Mari A, Ciociaro D, Positano V, Buzzigoli E, Ghione S, Turchi S, Lombardi M, Ferrannini E. Visceral fat in hypertension: influence on insulin resistance and beta-cell function. Hypertension 2004;44:127-33. https://doi.org/10.1161/01.HYP.0000137982.10191.0a
  12. Taguchi R, Takasu J, Itani Y, Yamamoto R, Yokoyama K, Watanabe S, Masuda Y. Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 2001;157:203-9. https://doi.org/10.1016/S0021-9150(00)00709-7
  13. Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, Leonetti F. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003;11:304-10. https://doi.org/10.1038/oby.2003.45
  14. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003;88: 5163-8. https://doi.org/10.1210/jc.2003-030698
  15. Park EM, Choi JH, Shin IS, Yun KH, Yoo NJ, Oh SK, Kim NH, Jeong JW. Echocaridographic epicardial fat thickness on short term prognosis in patients with acute coronary sydrome. J Cardiovasc Ultrasound 2008;16:42-7. https://doi.org/10.4250/jcu.2008.16.2.42
  16. Malavazos AE, Ermetici F, Cereda E, Coman C, Locati M, Morricone L, Corsi MM, Ambrosi B. Epicardial fat thickness: relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity. Nutr Metab Cardiovasc Dis 2008;18:523-30. https://doi.org/10.1016/j.numecd.2007.09.001
  17. Malavazos AE, Ermetici F, Coman C, Corsi MM, Morricone L, Ambrosi B. Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity. Int J Cardiol 2007;121:132-4. https://doi.org/10.1016/j.ijcard.2006.08.061
  18. Sacks HS, Fain JN. Human epicardial adipose tissue: a review. Am Heart J 2007;153:907-17. https://doi.org/10.1016/j.ahj.2007.03.019
  19. Iacobellis G, Willens HJ, Barbaro G, Sharma AM. Threshold values of high-risk echocardiographic epicardial fat thickness. Obesity (Silver Spring) 2008;16:887-92. https://doi.org/10.1038/oby.2008.6

Cited by

  1. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features vol.22, pp.11, 2009, https://doi.org/10.1016/j.tem.2011.07.003
  2. MRI Measured Epicardial Adipose Tissue Thickness at the Right AV Groove Differentiates Inflammatory Status in Obese Men With Metabolic Syndrome vol.20, pp.3, 2012, https://doi.org/10.1038/oby.2011.155
  3. Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosi vol.41, pp.5, 2009, https://doi.org/10.1177/0300060513496169
  4. Association of Adiponectin Gene Polymorphism (+T45G) With Acute Coronary Syndrome and Circulating Adiponectin Levels vol.64, pp.4, 2009, https://doi.org/10.1177/0003319712455497
  5. The relation of location-specific epicardial adipose tissue thickness and obstructive coronary artery disease: systemic review and meta-analysis of observational studies vol.14, pp.None, 2009, https://doi.org/10.1186/1471-2261-14-62
  6. Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population vol.12, pp.None, 2009, https://doi.org/10.1186/1476-7120-12-35
  7. Epicardial adipose tissue is related to coronary collateral vessel formation in patients with acute coronary syndrome vol.49, pp.3, 2015, https://doi.org/10.3109/14017431.2015.1023345
  8. Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis vol.10, pp.9, 2009, https://doi.org/10.19082/7249
  9. The epicardial adipose tissue and the coronary arteries: dangerous liaisons vol.115, pp.6, 2009, https://doi.org/10.1093/cvr/cvz062
  10. The association between epicardial adipose tissue thickness around the right ventricular free wall evaluated by transthoracic echocardiography and left atrial appendage function vol.36, pp.4, 2009, https://doi.org/10.1007/s10554-019-01748-w
  11. Mouse model of the adipose organ: the heterogeneous anatomical characteristics vol.44, pp.9, 2021, https://doi.org/10.1007/s12272-021-01350-6