Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Application of Cl3CCONH2/PPh3 towards the Synthesis of Bioactive Amides

  • Published : 2009.09.20
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Abstract

$Cl_3CCONH_2$ coupled with $PPh_3$ was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.

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References

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