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Korean Chemical Society (대한화학회)
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Gamnamoside, a Phenylpropanoid Glycoside from Persimmon Leaves (Diospyros kaki) with an Inhibitory Effect against an Alcohol Metabolizing Enzyme

  • Varughese, Titto (Department of Chemistry, Kongju National University) ;
  • Rahaman, Mozahidur (Department of Chemistry, Kongju National University) ;
  • Kim, No-Soo (Department of Cosmetic Science and Technology, Youngdong University) ;
  • Cho, Soon-Chang (Department of Cosmetic Science and Technology, Youngdong University,Center for Senior Industry) ;
  • Moon, Surk-Sik (Department of Chemistry, Kongju National University)
  • Published : 2009.05.20
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Abstract

Phytochemical investigation of the methanolic extract of Diospyros kaki leaves led to the isolation of osmanthuside H (1) and a new phenol glycoside, named gamnamoside [4-(3-hydroxypropyl)-2-methoxyphenol $\beta$-D-apiofuranosyl( 1 $\rightarrow$ 6)$\beta$-D-glucopyranoside] (2) along with (-) catechin (3) through a series of reversed phase column chromatography and preparative C18 HPLC. The structures of the isolates were determined by spectroscopic methods including IR, UV, HRTOFMS, and 2D NMR. Compounds 1, 2, and 3, showed good inhibitory activities ($IC_{50}$) of 175.4, 94.4, and 126.6 ${\mu}g/mL$ respectively, whereas a reversible ADH inhibitor, 4-methylpyrazole, showed the $IC_{50}$ of 326.6 ${\mu}g/mL$ against alcohol dehydrogenase (ADH).

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References

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