Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Tris(2-methoxyphenyl)phosphine as a Highly Active Ligand for the Synthesis of Biaryls by Suzuki Coupling Reaction

  • Published : 2009.11.20
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Abstract

A $Pd(OAc)_2/(o-MeOPh)_3P$ system has been developed for the catalytic Suzuki coupling of aryl bromides with arylboronic acids. Our catalyst system covers a broad spectrum of commonly available arylboronic acids and aryl bromides to provide biaryls in very good yields. The catalyst system works very well in the synthesis of sterically hindered biaryls.

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References

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  1. Observation of Binuclear Palladium Clusters upon ESI-MS Monitoring of the Suzuki–Miyaura Cross-Coupling Catalyzed by a Dichloro-bis(aminophosphine) Complex of Palladium vol.30, pp.13, 2011, https://doi.org/10.1021/om200274z