Bulletin of the Korean Chemical Society

  • 제30권9호
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  • Pages.2027-2031
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antiproliferative Activities of 1-Substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole Derivatives Against Melanoma Cell Line

  • Choi, Won-Kyoung (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Biomaterials Research Center, Korea Institute of Science and Technology)
  • 발행 : 2009.09.20
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초록

The synthesis of a new series of diarylureas and amides having a 1-substituted-3-(3-chloro-5-methoxyphenyl)-4- pyridinylpyrazole scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. Most of the newly synthesized compounds generally showed superior or similiar activity against A375 to Sorafenib. Among these compounds, IId, IIg and IIh showed excellent activity against A375 compared to Sorafenib.

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참고문헌

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피인용 문헌

  1. Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line vol.33, pp.11, 2012, https://doi.org/10.5012/bkcs.2012.33.11.3635
  2. Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold vol.34, pp.8, 2013, https://doi.org/10.5012/bkcs.2013.34.8.2480
  3. Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages vol.26, pp.9, 2017, https://doi.org/10.1007/s00044-017-1923-9
  4. ChemInform Abstract: Synthesis and Antiproliferative Activities of 1-Substituted-3-(3-chloro-5-methoxyphenyl)-4-pyridinylpyrazole Derivatives Against Melanoma Cell Line. vol.41, pp.7, 2010, https://doi.org/10.1002/chin.201007128
  5. Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines vol.46, pp.8, 2009, https://doi.org/10.1016/j.ejmech.2011.04.031
  6. New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking stud vol.46, pp.12, 2009, https://doi.org/10.1016/j.ejmech.2011.08.013
  7. Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties vol.34, pp.1, 2019, https://doi.org/10.1080/14756366.2019.1653292