Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Analysis of Chemical Warfare Agents in Water Using Single-Drop Microextraction

  • Park, Yang-Gi (Department of Chemistry and Environmental Analysis, Chemical Defense Research Institute) ;
  • Kim, Sung-Ki (Department of Chemistry and Environmental Analysis, Chemical Defense Research Institute) ;
  • Choi, Ki-Hwan (Department of Chemistry, Seoul National University) ;
  • Son, Byung-Hoon (Department of Chemistry and Environmental Analysis, Chemical Defense Research Institute) ;
  • Park, Ju-Sub (Department of Chemistry and Environmental Analysis, Chemical Defense Research Institute) ;
  • Kang, Hong-Ku (Department of Chemistry and Environmental Analysis, Chemical Defense Research Institute)
  • Published : 2009.01.20
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Abstract

Single-drop microextraction (SDME) is an extraction methodology where the drop plays an essential role as extracts. It was evaluated for the GC-MS determination of nerve agents, one class of the chemical warfare agents (CWAs). Since these nerve agents are highly toxic, it is important to detect the nerve agents in the environmental samples. Several affecting factors including extraction solvents, stirring rate, extraction time, and amounts of salt were optimized. The limit of detections (LODs) were 0.1 - 10 ng/mL and the relative standard deviations (RSDs%, n=5) were in the range of 6.3% to 9.0% for four nerve agents. Without pretreatment of the environmental samples, 5-103 fold enrichments and 48-100% recovery were accomplished. These results demonstrated the feasibility of this method for on-site and off-site analysis of water sample collected from suspicious CWAs site.

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