Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Two New Antiinflammatory Triterpene Saponins from the Egyptian edicinal Food Black Cumin (Seeds of Nigella sativa)

  • Elbandy, Mohamed (Department of Oceanography, Kunsan National University) ;
  • Kang, Ok-Hwa (Department of Food Sciences and Technology, Faculty of Environmental Agricultural Sciences, Suez Canal University) ;
  • Kwon, Dong-Yeul (College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Rho, Jung-Rae (College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
  • Published : 2009.08.20
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Abstract

An extensive phytochemical investigation of the polar fractions of a methanolic extract of Egyptian medicinal food, black cumin (seeds of Nigella sativa L.) led to the isolation of two new triterpene saponins, named sativosides A and B (1-2), along with four known saponins (3-6). Sativoside A (1) is the first example of saponins containing 18-ene triterpene aglycon not only in this Nigella genus but also in the family Ranunculaceae. The structure of the new saponins was elucidated mainly by a combination of 1D and 2D NMR data, together with HRFABMS and acid hydrolysis. Three compounds (1-3) showed the significant inhibition effect of phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced production of IL-6 in a human mast cell (HMC-1) line.

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