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Imprint Cytology of Hepatic Angiomyolipoma -A Case Report -

간에 발생한 혈관근육지방종의 압착도말 세포 소견 -1예 보고-

  • Kim, Ae-Ri (Department of Pathology, Yeungnam University College of Medicine) ;
  • Kim, Hong-Jin (Department of Surgery, Yeungnam University College of Medicine) ;
  • Choi, Joon-Hyuk (Department of Pathology, Yeungnam University College of Medicine)
  • 김애리 (영남대학교 의과대학 병리학교실) ;
  • 김홍진 (영남대학교 의과대학 외과학교실) ;
  • 최준혁 (영남대학교 의과대학 병리학교실)
  • Published : 2008.09.30

Abstract

Angiomyolipoma of the liver is a rare benign tumor that's composed of variable mixtures of adipose tissue, smooth muscle and thick-walled blood vessels. We report here on the imprint cytologic features of a hepatic angiomyolipoma in a 47-year-old man. The smears showed spindle and epithelioid tumor cells in clusters, trabeculae and single cells. The spindle cells had elongated, cigar-shaped nuclei with finely granular chromatin and fibrillary cytoplasm. The epithelioid cells had round nuclei with a moderate amount of cytoplasm. Any adipose tissue was not found. Immunohistochemically, both the spindle and epithelioid cells revealed cytoplasmic positivity for smooth muscle actin and HMB-45.

Keywords

References

  1. Nguyen GK, Catzavelos C. Solitary angiomyolipoma of the liver. Report of a case initially examined by fine needle aspiration biopsy. Acta Cytol 1990;34:201-4
  2. Ma TK, Tse MK, Tsui WM, Yuen KT. Fine needle aspiration diagnosis of angiomyolipoma of the liver using a cell block with immunohistochemical study. A case report. Acta Cytol 1994;38:257-60
  3. Blasco A, Vargas J, de Agustín P, López-Carreira M. Solitary angiomyolipoma of the liver. Report of a case with diagnosis by fine needle aspiration biopsy. Acta Cytol 1995;39:813-6
  4. Villari D, Grosso M, Vitarelli E, Tuccari G, Barresi G. Nuclear pseudoinclusions in fine-needle aspiration cytology of hepatic angiomyolipoma: case report. Diagn Cytopathol 2000;22:390-3 https://doi.org/10.1002/(SICI)1097-0339(200006)22:6<390::AID-DC12>3.0.CO;2-M
  5. Khalbuss WE, Fischer G, Bazooband A. Imprint cytology of epithelioid hepatic angiomyolipoma: mimicry of hepatocellular carcinoma. Acta Cytol 2007;51:670-2
  6. Lin KJ, Eng HL, Lu SN, Chiu KW, Kuo FY. Hepatic angiomyolipoma: report of two cases with emphasis on smear cytomorphology and the use of cell block with immunohistochemical stains. Diagn Cytopathol 2004;31:263-6 https://doi.org/10.1002/dc.20104
  7. Yim HL, Park KW, Lee KB. Multiple angiomyolipoma of the liver: report of a case with diagnosis by fine needle aspiration cytology. Korean J Cytopathol 1998;9: 79-84
  8. Ishak KG, Anthony PP, Niederau C, Nakanuma Y. In : Hamilton SR, Aaltonen LA. World Health Organization classification of tumours: pathology and genetics of digestive system. Lyon: IARCPress, 2000;193
  9. Tsui WM, Colombari R, Portmann BC, et al. Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. Am J Surg Pathol 1999;23:34-48 https://doi.org/10.1097/00000478-199901000-00004
  10. Wang SN, Tsai KB, Lee KT. Hepatic angiomyolipoma with trace amounts of fat: a case report and literature review. J Clin Pathol 2006;59:1196-9
  11. Xu AM, Zhang SH, Zheng JM, Zheng WQ, Wu MC. Pathological and molecular analysis of sporadic hepatic angiomyolipoma. Hum Pathol 2006;37:735-41 https://doi.org/10.1016/j.humpath.2006.01.028
  12. Atkinson BF. Atlas of diagnostic cytopathology. 2nd ed. Philadelphia: Saunders, 2004; 554-5
  13. Guy CD, Yuan S, Ballo MS. Spindle-cell lesions of the liver: diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol 2001;25:94-100 https://doi.org/10.1002/dc.2011
  14. Ishak KG, Goodman ZD, Stocker JT. Atlas of tumor pathology. Tumors of the liver and intrahepatic bile ducts. 3rd series Fascicle 31. Washington, D.C.: Armed Forces Institute of Pathology, 2001;99-108
  15. Dalle I, Sciot R, de Vos R, et al. Malignant angiomyolipoma of the liver: a hitherto unreported variant. Histopathology 2000;36:443-50 https://doi.org/10.1046/j.1365-2559.2000.00891.x
  16. Parfitt JR, Bella AJ, Izawa JI, Wehrli BM. Malignant neoplasm of perivascular epithelioid cells of the liver. Arch Pathol Lab Med 2006;130:1219-22
  17. Nguyen TT, Gorman B, Shields D, Goodman Z. Malignant hepatic angiomyolipoma: report of a case and review of literature. Am J Surg Pathol 2008;32:793-8 https://doi.org/10.1097/PAS.0b013e3181607349