Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Amelioration of Asthmatic-Related Symptoms by an Aqueous Extract of Angelica archangelica L.

신선초의 물 추출물에 의한 천식 증상의 감소

  • Heo, Jin-Chul (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology Kyungpook National University) ;
  • Lee, Sang-Han (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology Kyungpook National University)
  • 허진철 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 이상한 (경북대학교 식품생물산업연구소 및 식품공학과)
  • Published : 2008.10.30
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Abstract

Inflammation through the respiratory tract is a crucial event in immune disorders, including asthma, and atopic rhinitis. To investigate whether an aqueous extract of Angelica archangelica L. (AaL) has a beneficial influence in terms of anti-asthmatic activity, its effects on an ovalbumin-induced asthmatic model were examined. Mice sensitized to ovalbumin were orally administered the AaL extract, and their lungs examined by Haematoxylin-Eosin staining to determine IL-4/13 cytokine expression. The AaL extract exerted strong anti-asthmatic effects by regulating each level in the $CD4^+$ cell number, IL-4/13, and other target markers in the lungs. Together, these results collectively indicate that the aqueous AaL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.

기관지를 통하여 발병하는 염증은 대표적인 면역질환의 현상인데 천식이나 아토피 피부염 등에 나타난다. 신선초의 물 추출물이 항천식 활성을 나타내는지를 알아보기 위하여 ovalbumin으로 유도시킨 동물모델을 사용하였다. 마우스에 경구투여하여 폐의 조직을 Haematoxylin-Eosin 염색과 면역조직화학을 이용하여 인터루킨-4 및-13의 발현을 측정한 결과, 신선초의 물 추출물은 $CD4^+$ 세포의 수 및, 인터루킨-4 및 -13의 발현을 억제하는 것으로 나타났다. 이의 결과는 신선초의 물 추출물이 ovalbumin 으로 유도시킨 마우스의 천식 증상을 경감시키는 것으로 이의 활용이 기대된다.

Keywords

References

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