Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

Daphnia magna를 이용한 세리아, 실리카, 티타늄 나노물질의 유전독성 평가

Genotoxicity of $CeO_2$, $SiO_2$ and $TiO_2$ Nanoparticles in the Freshwater Crustacean Daphnia magna

  • 김성만 (서울시립대학교 환경공학부 독성학연구실) ;
  • 최진희 (서울시립대학교 환경공학부 독성학연구실)
  • Kim, Sung-Man (Faculty of Environmental Engineering, College of Urban Study, University of Seoul) ;
  • Choi, Jin-Hee (Faculty of Environmental Engineering, College of Urban Study, University of Seoul)
  • 발행 : 2008.06.30
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초록

본 연구에서는, 세리아($CeO_2$), 실리카($SiO_2$) 및 티타늄($TiO_2$) 나노입자의 유전독성과 생태독성 평가를 위하여 바이오 모니터링에 널리 이용되는 수생생태 감시종인 Daphnia magna를 사용하였다. 합성한 나노입자 세리아와 공업적으로 상용되는 실리카 및 티타늄을 유전독성 및 생태독성평가에 이용하였다. 세리아의 경우, D. magna의 DNA의 파괴가 증가함을 통해 세리아의 유전독성 가능성을 확인할 수 있었으나, 실리카 및 티타늄의 경우에는 두 물질 모두 유전독성 영향이 나타나지 않았다. 실리카는 DNA에는 영향을 미치지 않는 것으로 보이나, 실리카에 노출된 D. magna의 사멸은 증가하는 결과를 보였다. 그러나, 티타늄에 노출된 D. magna에서는 유전독성 및 생태독성 인자의 유의적인 변화를 관찰할 수 없었다. 이상의 전체 결과를 통하여 예상할 수 있는 것은 세리아 나노입자가 D. magna에 유전독성을 일으킬 수 있다는 점이다. 이 결과는 나노입자가 광범위하게 이용되고 있으나 독성 관련 자료가 미약한 현재에 수생태 관련 독성 연구 결과로서 이바지 할 수 있을 것으로 여겨진다.

키워드

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