대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권1호
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- Pages.200-218
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- 2008
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- 1226-9174(pISSN)
인진청간탕(茵蔯淸肝湯)이 DMN 유발 간섬유화와 단백질 발현에 미치는 영향
The Effects of Injinchunggan-tang(Yinchenqinggan-tang) on DMN-induced Liver Damage by Applying Proteomics
- 박상백 (경희대학교 한의과대학 간계내과학교실) ;
- 김영철 (경희대학교 한의과대학 간계내과학교실) ;
- 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
- 우홍정 (경희대학교 한의과대학 간계내과학교실)
- Park, Sang-Baek (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Kim, Young-Chul (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Lee, Jang-Hoon (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Woo, Hong-Jung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
- 발행 : 2008.03.31
초록
Objectives : The purpose of this study was to investigate the effects of Injinchunggan-tang (Yinchenchinggan-tang) on DMN-induced liver damage by applying proteomics. Materials and Methods : Sprague-Dawley rats were used in this experiment and were divided into the normal group (normal saline), the control group (DMN) and the sample group (DMN+IJCGT). DMN was injected i.p. once a day three times a week for 3 weeks in the control group. Normal saline instead of DMN was administered to the normal group. In the sample group, Injinchunggan-tang (Yinchenchinggan-tang) extract was orally administered once a day for 10 days after DMN was induced. The livers of each group were processed and analyzed by histology, Western blot,