The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지

Effect of Job's Tear(Yul-Moo) Extracts on Mouse Oral Administration $IL-l{\beta}$, IL-6, $TNF-{\alpha}$, IL-10 Cytokine Production by Peritoneal Macrophage for Two Weeks

2주 동안의 율무 추출물 경구 투여가 복강대식세포의 사이토카인 $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, IL-10 생성에 미치는 영향

  • Ryu, Hye-Sook (Dept. of Food and Nutrition, College of Health Sciences, Sangji University)
  • 류혜숙 (상지대학교 보건과학대학 식품영향학과)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The present study examined the ex vivo effect of Job's tear on immune function. Seven to eight week old mice(Balb/c) were fed a chow diet ad libitum two different concentrations (50 and 500 mg/kg BW) of water extract of Job's tear were orally administ every other day for two weeks. The results indicated that macrophage activation had occurred in the mice receiving 50 mg/kg B. W. of Job's tear water extract. Overall, using a mouse model, this study demonstrated that Job's tear extract may enhance immune function by regulating the $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ and IL-10 cytokine production capacity of activated macrophages in mice. This study may suggest that supplementation of Job's tear water extracts may enhance the immune function by regulating the enhancing the cytokine production by activated macrophage ex vivo.

Keywords

References

  1. Yee, ST and Chang, SH. The effect of Korean mistletoe extract M11C on $IL-1<\beta$ release and expression from macrophages. Immune Network. 2:170-178. 2001
  2. Kim, HP, Son, KH and Kang, SS. Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacological Sci. 96:229-245. 2004 https://doi.org/10.1254/jphs.CRJ04003X
  3. Park, JS and Chyun, JH. Effects of low fat diet and saturated fat supplementation on the immune status of BALB/c mouse. Kor. J. Nutr. 26:578-585. 1993
  4. Pyo, MY and Su, MH. Effects of Phellinus linteus extracts on the humoral immune response in normal and cyclophosphamide- treated mice. J. of Applied Pharmacol. 9: 194-200. 2001
  5. Wagner, H. Search for plant derived natural products with immunostimulatory activity. Pure ＆ Appl. Chem. 66:1271-1274. 1990
  6. Kim, GH and Sunwoo, YK. Effects of small water dropwort extract on cellular immune response of mice. J. Bacteriol. Virol. 28:419-430. 1993
  7. Park, HA. Enhancing effect of Ixeris sonchifolia Hance Oenanthe javanica and Fagopyrum escluentum Moench on mouse immune cell activation. Master's Thesis, Sookmyung Women's Uni., 2003
  8. Park, KY and Rhee, SH. The antitumor effect in sarcoma-180 tumor cell of mice administered with Japanese apricot, garlic ginger doenjang. J. Kor. Soc. Food Sci. Nutr. 21:599-606. 2005
  9. Ko, MS, Shin, KM and Lee, MY. Effects of Hizikia fusiforme ethanol extract on antioxidative enzymes in ethanol induced hepatotoxicity of rat liver. J. Kor. Soc. Food Sci. Nutr. 31: 87-91. 2002 https://doi.org/10.3746/jkfn.2002.31.1.087
  10. Yun, HJ. Effect of Hizikia fusiforme water extracts on mouse immune cell activation. Master's Thesis, Sookmyung Women's Uni., 2003
  11. Chae, KY and Hong, JS. The quality charateristics of jeolpyon with different amounts of Job`s Tears flour. J. Kor. Soc. Food Sci. 5:770-776. 2007
  12. Kim, HP, Son, KH and Kang, SS. Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacological Sci. 96:229-245. 2004 https://doi.org/10.1254/jphs.CRJ04003X
  13. Ryu, HS, Kim, Jin and Kim, HS. Enhancing effect of Sorghum bicolor L. Moench(Sorghum, su-su) extracts on mouse spleen and macrophage cell activation. Kor. J. Food & Nutr. 19: 176-182. 2006
  14. Ryu, HS. Effects of Job's tears(yul-moo) extracts on mouse splenocyte and macrophage cell activation. Kor. J. Food & Nutr. 21:1-6. 2008
  15. Park, Y, Suzuki, H and Lee, YS. Effect of coxi on plasma, liver and fecal lipid components in the rat fed on lard or soybean oil-cholesterol diet. Biochem Med. Metab. Biol. 39:7-10. 1988
  16. Ary, MB, Richardson, M and Shewry, PR. Purification and characterization of an insect alpha-amylase inhibitor/endochitinase from seeds of Job's tears. Biochem. Biophys. Acta. 999:260-266. 1988
  17. Kwon, SJ, Lim, CY and Lee, SY. Fibrinolytic activities and effect gamma-irradiated on seeds from Coix lacryma-jobi L., Carthamus tinctorius L. and Malva verticillata L. Kor. J. Biotechnol. Bioeng. 21:20-27. 2006
  18. Kwak, CS, Lim, SJ, Kim, SA, Park, SC and Lee, MS. Antioxidative and antimutagenic effects of Korean buckwheat, sorghum, millet and Job`s Tears. J. Food Sci. Nutr. 6: 921-929. 2004
  19. Cho, SH, Yang, KM, Bae, BS, In, SA and Yu, RN. Effect of sea tangle intake on cytokine production in macrophage from normal and diabetic mice. J. Food Sci. Nutr. 27: 952-959. 1988
  20. Ryu, BH, Kim, DS, Cho, KJ and Sin, DB. Antitumor activity of seaweeds toward sarcoma-180. Kor. J. Food Sci. Technol. 25:595-596. 1987
  21. Shan, BE, Yoshida, Y, Kuroda, E and Yamashira, U. Immunomodulating activity of seaweed extract on human lymphocytes in vitro. Int. J. Immunopharmacol. 21:59-70. 1999 https://doi.org/10.1016/S0192-0561(98)00063-0
  22. Park, HR, Kim, SH, Yee, ST, Byun, MW and Jo, SK. Effect of a herb mixture(Him-1) on the protection of the henatopoietic immune system and self-renewal tissues against radiation damage. J. Kor. Soc. Food Sci. Nutr. 34:605-612. 2005 https://doi.org/10.3746/jkfn.2005.34.5.605
  23. Trinchieri, G. A proinflammatory cytokine with immunoregulatory function that bridge innate resistantce and antigen- specific adaptive immunity. Ann. Rev. Immunol. 13:251-276. 1995 https://doi.org/10.1146/annurev.iy.13.040195.001343