Progress in Medical Physics (한국의학물리학회지:의학물리)

Korean Society of Medical Physics (한국의학물리학회)
권호 표지

Assessment on Gastrointestinal Transit Movement of Capsule Endoscopy in Beagle Dogs

비글견에서 캡슐 내시경의 위장관 이동분석 평가

  • Chang, Hwa-Seok (Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University) ;
  • Yang, Hee-Taek (Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Sang-Youn (Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea) ;
  • Woo, Dong-Cheol (Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea) ;
  • Park, Woo-Dae (Department of Pet Science, Seojung College) ;
  • Yong, Joon-Hwan (Department of Occupational Theraphy, Dongnam Health College) ;
  • Choe, Bo-Young (Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hwi-Yool (Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University) ;
  • Choi, Chi-Bong (Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea)
  • 장화석 (건국대학교 수의과대학 수의외과학교실) ;
  • 양희택 (건국대학교 수의과대학 수의외과학교실) ;
  • 김상영 (가톨릭대학교 의과대학 의공학교실) ;
  • 우동철 (가톨릭대학교 의과대학 의공학교실) ;
  • 박우대 (서정대학 애완동물과) ;
  • 용준환 (동남보건대학 작업치료과) ;
  • 최보영 (가톨릭대학교 의과대학 의공학교실) ;
  • 김휘율 (건국대학교 수의과대학 수의외과학교실) ;
  • 최치봉 (가톨릭대학교 의과대학 의공학교실)
  • Published : 2008.06.30
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Abstract

The object of this study is to measure the transit time and passage rate of capsule endoscopy (CE) in the gastrointestinal tract in medium sized beagle dogs ($7{\sim}13\;kg$). Animals were divided into four groups: only capsule (group 1, n=10), capsule+water (group 2, n=10), mettoclopramide+capsule (group 3, n=10), metoclopramide +capsule+water (group 4, n=10). The capsule transit times through the stomach and small bowel were evaluated by radiography findings. Gastric transit time (GTT), small intestinal transit time (SITT) and complete passage rate were measured in four groups. GTT's for each group were as follows; $45{\pm}20\;min$ (group 1), $117{\pm}35\;min$ (group 2), $150{\pm}40\;min$ (group 3), and $154{\pm}65\;min$ (group 4), while SITT's were $75{\pm}20\;min$ (group 1), $195{\pm}55\;min$ (group 2), $70{\pm}15\;min$ (group 3), and $76{\pm}15\;min$ (group 4). The complete passage rates were 20% (group 1), 40% (group 2), 20% (group 3), 50% (group 4). In all groups, if CE could pass through the pylorus, it passed all small intestinal tracts within 8 hours (battery life). Administration of water helped CE to pass pylori, except in case of metoclopramide administration. These results indicate that CE could be an useful tool for examining gastrointestinal diseases in the veterinary medicine.

수의 임상에서 캡슐 내시경(capsule endoscopy, CE)의 사용에 기본적인 기준과 유용성을 정립하기 위하여 정상 중형견($7{\sim}13\;kg$)에서 캡슐의 위 통과시간(gastric transit time, GTT), 작은창자 통과시간(small intestinal transit time, SITT), 완전통과율(complete transit time, CTT)을 측정하고 통과율을 분석하였다. 1군(capsule 투여), 2군(capsule+water 투여), 3군(metoclopramide+capsule 투여) 그리고 (metoclopramide+capsule+water 투여)의 총 4군으로 나누어 방사선 촬영을 통하여 평가를 실시했다. GTT는 평균 $45{\sim}20\;min$ (group 1), $117{\pm}35\;min$ (group 2), $150{\pm}40\;min$ (group 3), $154{\pm}65\;min$ (group 4)였으며 SITT는 평균 $75{\pm}20\;min$ (group 1), $195{\pm}55\;min$ (group 2), $75{\pm}15\;min$(group 3), $76{\pm}15\;min$ (group 4)로 나타났다. 완전통과율(complete passage rate)은 각각 20% (group 1), 40%, (group 2), 20% (group 3), 50% (group 4)로 나타났다. 실험결과 캡슐이 유문부를 통과하기만 하면 내시경 캡슐 배터리 수명인 8시간 이내로 위장관을 모두 통과하였으며 물을 위내로 투여한 후 volume의 증가에 의한 위 운동성의 증가는 캡슐의 유문부 통과에 도움이 되었다. 그러나 metoclopramide의 투여는 유문부의 통과와 SITT의 시간에 대한 유의적인 효과가 나타나지 않았다.

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