Journal of Korean Academy of Nursing (대한간호학회지)

Korean Society of Nursing Science (한국간호과학회)
권호 표지

Body Fat Percentage and Natural Killer Cell Activity of Breast and Rectal Cancer Patients after Diagnosis but before Treatment

진단 직후 유방암.직장암 환자의 체지방량과 자연 살 세포 활동량

  • Published : 2008.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: To examine the relationship between body fat percentage (BFP) and N-K cell activity (NKCA) in Korean breast and rectal cancer patients just after diagnosis. Methods: With 35 subjects enrolled between November 2002 and May 2003, Bioelectrical Impedance Analysis was used to estimate BFP. FACS Analysis was used to measure N-K cell activity. The relationships between BFP and NKCA were identified by using curve estimation, simple regression, and multiple regression, Results: The mean BFPs of the subjects and all the sub-groups were higher than acceptable BFPs. Both the mean NKCAs of male and female subjects were lower than that of healthy women. NKCA was explained by BFP with a 14.9% variance in the total subjects (p<.05). There were significant negative relationships between BFP and NKCA after controlling age, type of cancer, and stage of cancer while no significant relationship was found after controlling for gender. The relationships between BFP and NKCA in the sub-groups of female, breast cancer, and stage I, and II were significant. The relationships between male, rectal cancer, and the stage III, and VI sub-groups were not identified, but they revealed a mild to moderate steep in curve estimation. Conclusion: Weight reduction could prevent the risk and advancement of breast and rectal cancer in Koreans.

Keywords

References

  1. Ahn, S. H., Park, K. C., Youn, Y. Y., Lee, M. S., Kim, Y. S., Kim, M. K., et al. (1996). A case- control study on the risk factors of breast cancer in Korea. Journal of Korean Surgical Society, 50, 26-35
  2. American Cancer Society. (2007, October). What are the risk factors of breast cancer. Retrieved October 22, 2007, from the American Cancer Society, Web site: http//www.cancer.org/docroot/CRI
  3. Bovbjerg, D. H., Valdimarsdottir, H. B., & Zachariae, R. (1999). Psychoneuroimmunology in oncology. In M. Scheldlowski & U. Tewes (Eds.), Psychoneuroimmunology: An interdisciplinary introduction (pp.473-486). New York: Kluwer Academic Plenum Publishers
  4. Breast cancer news. (2006, October). Abdominal fat affect breast cancer survival. Retrieved July 26, 2007, from the Breast Cancer News, the Medical News Today Web site: http://www.medicalnewstoday. com
  5. Dhabhar, F. S., & McWen, B. S. (2001). Bidirectional effects of stress and glucocorticoid hormones on immune function: Possible explanations for paradoxical observations. In R. Ader, D.L. Felton, & N. Cohen (Eds.). Psychoneuroimmunology (3rd ed., vol 2, pp. 301-338). San Diego: Academic Press
  6. Draper, L. (2006). Breast cancer: trends, risks, treatments, and effects. Official Journal of the American Association of Occupational Health Nurses, 54, 445-451
  7. Fact sheet #42. (2001, August). A woman's body type and the risk of breast cancer. Retrieved July 26, 2007, from program on breast cancer and environmental risk factors, Sprecher Institute, Cornell University Web site: http://envirocancer.cornell.edu/Fact-Sheet/General
  8. Feigelson, H. S., Patel, A. V., Teras, L. R., Gansler, T., Thun, M. J., & Calle, E. E. (2006). Adult weight gain and histopathologic characteristics of breast cancer among postmenopausal women. Cancer, 107, 12-21 https://doi.org/10.1002/cncr.21965
  9. Health Information Publications. (2002-2005). Breast cancer. Retrieved July 26, 2007, from the EhealthMD Web site http://www.ehealthmd.com
  10. Health Check Systems. (1997, July). Understanding your body fat percentage. Retrieved July 26, 2007, from the Health Check Systems Web site: http://www.healthchecksystems.com
  11. Kelley, D. S., Daudu, P. A., Branch, L. B., Johnson, H. L., Taylor, P. C., & Mackey, B. (1994). Energy restriction decrease number of circulating natural killer cells and serum levels of immunoglobulins in overweight women. European Journal of Clinical Nutrition, 48, 9-18
  12. Kim, D. S. (2005). Comparison of N-K cell level between normal person and the cancer patients just after diagnosis. Chungnam Journal of Nursing Academy, 8(2), 27-32
  13. Kim, E. K., Yang, Y. H., & Choi, K. S. (1999). Nutritional Status of Cancer Patients upon Admission. Journal of Korean Society of Nursing Science, 29, 272-280
  14. Lamas, O., Martinez, J. A., & Marti, A. (2004). Energy restriction restores the impaired immune response in overweight (cafeteria) rats. The Journal of Nutritional Biochemistry, 15, 418-425 https://doi.org/10.1016/j.jnutbio.2004.02.003
  15. Lee, S. A., Yoo, K. Y., Noh, D. Y., & Choe, K. J. (2003). Diet and the risk of breast cancer in Korean women- a case-control. Journal of Korean Breast Cancer Society, 6, 271- 276
  16. Lee, H. S., & Kim, Y. (2001). SPSS 10.0 Manual: Statistical analysis and interpretation. Seoul: Beop-Mun Co.
  17. Macinnis, R. J., English, D. R., Haydon, A. M., Hopper, J. L., Gertig, D. M., & Giles, G. G. (2006). Body size and composition and risk of rectal cancer (Australia). Cancer Causes &Control, 17, 1291-1297 https://doi.org/10.1007/s10552-006-0074-y
  18. Nieman, D. C., Henson, D. A., Nehlsen-Cannarella, S. L., Ekkens, M., Utter, A. C., Butterworth, D. E., et al. (1999). Influence of obesity on immune function. Journal of the American Diet Association, 99, 294-299 https://doi.org/10.1016/S0002-8223(99)00077-2
  19. Popkin, B. M. (2007). Understanding global nutrition dynamics as a step towards controlling cancer incidence. Nature reviews. Cancer, 7, 61-67
  20. Scanga, C. B., Verda, T. J., Paolone, A. M., Andersen, R. E., & Wadden, T. A. (1998). Effects of weight loss and exercise training on natural killer cell activity in obese women. Medicine and Science in Sports and Exercise, 30, 1666-1671 https://doi.org/10.1097/00005768-199812000-00002
  21. Schag, C. C., Heinrich, R. L., & Ganz, P. A. (1984). Karnofsky performance status revisited: Reliability, validity, and guidelines, Journal of Clinical Oncology, 2, 187-193 https://doi.org/10.1200/JCO.1984.2.3.187
  22. Semaninc, C., Chow, W. H., Gridley, G., Jarvholm, B., & Fraumeni, J. F. Jr. (2006). Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes &Control, 17, 901-909 https://doi.org/10.1007/s10552-006-0023-9
  23. Shade, E. D., Ulrich, C. M., Wener, M. H., Wood, B., Yasui, Y., LACroix, K., et al. (2004). Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects. Journal of American Diet Association, 104, 903-912 https://doi.org/10.1016/j.jada.2004.03.018
  24. Sothern, R. B., & Roitman-Johnson, B. (2001). Biological rhythm and immune function. In R. Ader, D. L. Felton, & N. Cohen (Eds.). Psychoneuroimmunology (3rd ed., vol2, pp.445-482). San Diego: Academic Press
  25. Turner-Cobb, J. M., Sephton, S. E., & Spiegel, D. (2001). Psychosocial effects on immune function and disease progression in cancer: Human studies. In R. Ader, D.L. Felton, & N. Cohen (Eds.). Psychoneuroimmunology (3rd ed., vol 2, pp. 565-582). San Diego: Academic Press
  26. Wang, S., & Lee, N. (2004). Comparison of body fat by biological impedance analysis and anthropometric measurements in women in Daejeon. Korean Journal of Life Science, 13, 1037-1046
  27. Yabro, C. H., Frogge, M. H., Goodman, M., & Groenwald, S. L. (2000). Cancer Nursing: Principles and Practice. Boston: The Jones and Bartlett Series