Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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A Case of Gastric MALT Lymphoma Presenting as Nodular Gastritis in a Child

소아에서 결절성 위염으로 발현한 위 점막연관림프조직 림프종 1예

  • Lee, Kun-Song (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Yang, Hye-Ran (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Ko, Jae-Sung (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Seo, Jeong-Kee (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Lee, Hye-Seung (Department of Pathology, Seoul National University Bundang Hospital)
  • 이건송 (서울대학교 의과대학 소아과학교실) ;
  • 양혜란 (서울대학교 의과대학 소아과학교실) ;
  • 고재성 (서울대학교 의과대학 소아과학교실) ;
  • 서정기 (서울대학교 의과대학 소아과학교실) ;
  • 이혜승 (분당서울대학교병원 병리학교실)
  • Received : 2008.07.23
  • Accepted : 2008.09.02
  • Published : 2008.09.30
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Abstract

Most cases of mucosa-associated lymphoid tissue (MALT) lymphoma occur in adults. MALT lymphoma is very rare in children. Helicobacter pylori (H. pylori) infection is known to be an important etiologic factor predisposing to the development of gastric MALT lymphoma. A 12-year-old girl was admitted because of intermittent abdominal pain occurring over the preceding 2 years. Nodular gastritis of the stomach was demonstrated on endoscopy. H. pylori infection was confirmed using the rapid urease test and histopathology. Histopathological examination of gastric biopsy specimens revealed lymphoepithelial lesions pathognomonic of MALT lymphoma, and immunohistochemical staining for CD20 was diffusely positive. Therefore, the patient was diagnosed with gastric MALT lymphoma. Clinical manifestations and histopathologic findings compatible with MALT lymphoma improved with the eradication of H. pylori infection. We report a case of primary gastric MALT lymphoma in a child, associated with H. pylori infection and presenting as nodular gastritis.

만성 복통을 주소로 내원한 12세 여아에서 내시경 소견상 결절성 위염과 조직 검사상 H. pylori 감염을 확인 하였으며, 병리 소견 및 면역조직화학 검사상 위 MALT 림프종으로 진단되어, H. pylori 제균 치료 후 결절성 위염의 호전과 위 MALT 림프종의 완전한 관해를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

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