References
- Gershon RK, Cohen P, Hencin,R, Liebhaber SA: Suppressor T cells. J Immunol 108;586-590, 1972
- Gershon RK, Kondo K: Infectious immunological tolerance. Immunology 21;903-914, 1971
- Ha TY, Waksman BH: Role of the thymus in tolerance .X. 'Suppressor' activity of antigen-stimulated rat thymocytes transferred to normal recipients. J Immunol 110;1290-1299, 1973
- Ha TY, Waksman BH, Treffers HP: Thymic suppressor cell. I. Separation of subpopulation with suppressor activity. J Exp Med 139;13-23, 1974 https://doi.org/10.1084/jem.139.1.13
- Ha TY, Waksman BH, Treffers HP: The thymic suppressor cell. II. Metabolic requirement of suppressor activity. Immunol Commun 3;351-359, 1974 https://doi.org/10.3109/08820137409061115
- Tada T, Taniguchi M, Takemori T: Properties of primed suppressor T cells and their products. Transplant Rev 26;106-129, 1975
- Gershon RK, Eardley DD, Durum S, Green R, Shen FW, Yamauci K, Cantor H, Murphy DB: Contrasuppression. A novel immunoregulatory activity. J Exp Med 153;1533-1546, 1981 https://doi.org/10.1084/jem.153.6.1533
- Gerber NL, Hardin JA, Chused TM, Steinberg AD: Loss with age in NZB/W mice of thymic suppressor cells in the graft-vs-host reaction. J Immunol 113;1618-1625, 1974
- Durkin HG, Waksman BH: Thymus and tolerance. Is regulation the major function of the thymus? Immunol Rev 182;33-57, 2001 https://doi.org/10.1034/j.1600-065X.2001.1820103.x
- Dorf ME, Benaceraf B: Suppressor cells and immunoregulation. Ann Rev Immunol 2;127-158, 1984 https://doi.org/10.1146/annurev.iy.02.040184.001015
- Mitrrucker HW, Kaufmann HE: Mini-review: regulatory T cells and infection: suppression revisited. Eur J Immunol 34;306-312, 2004 https://doi.org/10.1002/eji.200324578
- Baecher-Allan C, Hafler DA: Suppressor T cells in human diseases. J Exp Med 200;273-276, 2004 https://doi.org/10.1084/jem.20040812
- Waksman BH: Tolerance, the thymus, and suppressor T cells. Clin Exp Immunol 28;363-374, 1977
- Shevach EM: D4+: CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 182;389-400, 2002
- Rouse BT, Sehrawat S: Regulatory T cells and infectious disease. Immune Network 7;167-172, 2007 https://doi.org/10.4110/in.2007.7.4.167
- Basten A, Fazekas de St Groth B: Special regulatory T-cell review: T cell dependent suppression revisited. Immunol 123;33-39, 2008 https://doi.org/10.1111/j.1365-2567.2007.02772.x
- Tang Q, Bluestone JA: The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 9; 239-244, 2008 https://doi.org/10.1038/ni1572
- Ha TY, Chung HT: Effect of cyclophosphamide on humoral and cellular immune response in mice. J Korean Med Ass 20;985-994, 1977
- Ha TY, Kim HI, Im SY: Effect of dexamethasone on different types of murine T suppressor cells. Korean J Immunol 9;1-15, 1987
- Ha TY, Park YM, Park YK, Lee HK, Park CW: Regulation of cellular immunity in cryptococosis. III. Induction of Cryptococcus neoformans-specific T cells and hybridoma. Korean J Immunol 14;15-23, 1992
- Moeller G (Ed): Suppressor T lymphocytes. Transplantation Rev 26;3-205, 1975
- Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanisms of self-tolerance causes various autoimmune diseases. J Immunol 155;1151-1164, 1995
- Sakaguchi S: Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Ann Rev Immunol 22;531-562, 2004 https://doi.org/10.1146/annurev.immunol.21.120601.141122
- Mills KH: Regulatory T cells: friend or foe in immunity to infection? Nature Rev Immunol 4;841-855, 2004 https://doi.org/10.1038/nri1485
- Stein-Streilein J, Taylor AW: An eye's view of T regulatory cells. J Leukoc Biol 81;593-598, 2007 https://doi.org/10.1189/jlb.0606383
- Jiang S, Lechler RI: CD4+CD25+regulatory T-cell therapy for allergy, autoimmune and transplant rejection. Inflamm Allergy Drug Targets 5;239-242, 2006 https://doi.org/10.2174/187152806779010981
- Beyer M, Schultze JL: Regulatory T cells in cancer. Blood 1108;804-811, 2006
- Bluestone JA: Regulatory T-cell therapy: is it ready for the clinic? Nat Rev Immunol 5;343-349, 2005 https://doi.org/10.1038/nri1574
- Vignail DA, Collison LW, Workman CJ: How regulatory T cell work. Nat Rev Immunol 8;523-532, 2008 https://doi.org/10.1038/nri2343
- Bendelac A, Savage PB, Teyton L: The biology of NKT cells. Ann Rev Immunol 25;297-336, 2007 https://doi.org/10.1146/annurev.immunol.25.022106.141711
- Sakaguchi S, Powrie F: Emerging challenges in regulatory T cell function and biology. Science 317;627-629, 2007 https://doi.org/10.1126/science.1142331
- Kang SM, Tang Q. Bluestone JA: CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 7;1457-1463, 2007 https://doi.org/10.1111/j.1600-6143.2007.01829.x
- Thomson CW, Lee BP, Zhang L: Double-negative regulatory T cells: non-conventional regulators. Immunol Res 35;163-178, 2006 https://doi.org/10.1385/IR:35:1:163
-
Hayday A, Tigelaar R: Immunoregulation in the tissues by
$\gamma$ $\delta$ T cells. Nat Rev Immunol 3;233-242, 2003 https://doi.org/10.1038/nri1030 - Zhang C, Zhang J, Tian Z: 2006. The regulatory effect of natural killer cells: do 'NK-reg cells' exist? Cell Mol Immunol 3;241-254, 2006
- Hori S, Sakaguchi S: Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect 6;745-751, 2004 https://doi.org/10.1016/j.micinf.2004.02.020
- Ziegler SE: FOXP3: of mice and men. Ann Rev Immunol 24;209-226, 2006 https://doi.org/10.1146/annurev.immunol.24.021605.090547
- Stein-Streilein J, Taylor AW: An eye's view of T regulatory cells. J Leukoc Biol 81;593-598, 2007 https://doi.org/10.1189/jlb.0606383
- Hawrylowicz CM: Regulatory T cells and IL-10 in allergic inflammation. J Exp Med 202;1459-1463, 2005 https://doi.org/10.1084/jem.20052211
- Ford McIntyre MS, Young KJ, Gao J, Joe B, Zhang L: Cutting edge: in vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression. J Immunol 181;2271-2275, 2008 https://doi.org/10.4049/jimmunol.181.4.2271
- Young KJ, DuTemple B, Phillips MJ, Zhang L: Inhibition of graft versus host disease by double negative regulatory T cells. J Immunol 171;134-141, 2003 https://doi.org/10.4049/jimmunol.171.1.134
- Morgan ME, van Bilsen JH, Bakker AM, Heemskerk B, Schilham MW, Hartgers FC, Elferink BG, van der Anaden L, De Vies RR, Huizinga TW, Ottenhoff TH, Toes RE: Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Human Immunol 66;13-20, 2005
- Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T: Fox3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212;8-27, 2006 https://doi.org/10.1111/j.0105-2896.2006.00427.x
- Dejaco C, Duftner C, Grubeck-Loebsenstein B, Schirmer M: Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117;289-300, 2006 https://doi.org/10.1111/j.1365-2567.2005.02317.x
- Venken K, Hellings N, Thewissen M, Somers V, Hensen K, Rummens JL, Medaer R, Hupperts R, StinissenP: Compromised CD4+CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 123;79-89, 2008 https://doi.org/10.1111/j.1365-2567.2007.02690.x
- Zheng SG, Wang JH, Koss MN, Quisomorio F Jr, Gray JD, Horwitz DA: CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 172;1531-1539, 2004 https://doi.org/10.4049/jimmunol.172.3.1531
- Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, Sakaguchi S: Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27;145-159, 2007 https://doi.org/10.1016/j.immuni.2007.04.017
- Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, Sakaguchi S: Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27;145-159, 2007 https://doi.org/10.1016/j.immuni.2007.04.017
- Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL: Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGF beta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol 180;7327-7337, 2008 https://doi.org/10.4049/jimmunol.180.11.7327
- Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W: Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol 34;623-630, 2004 https://doi.org/10.1002/eji.200324799
-
Glinka Y, Pud'homme GJ: Neruopilin-1 is a receptor for transforming growth factor
$\beta$ -1, activates its latent form, and promotes regulatory T cell activity. J Leukoc Biol 84;302-310, 2008 https://doi.org/10.1189/jlb.0208090 - Coleman CA, Muller-Trutwin MC, Apetrei C, Pandrea I: T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med 11;1291-1325, 2007 https://doi.org/10.1111/j.1582-4934.2007.00087.x
- Sakaguchi S, Powrie F: Emerging challenges in regulatory T cell function and biology. Science 317;627-629, 2007 https://doi.org/10.1126/science.1142331
- Bacchetta R, Gambineri E, Roncarolo MG: Role of regulatory T cells and FOXP3 in human diseases. J Allergy Clin Immunol 120;227-235, 2007 https://doi.org/10.1016/j.jaci.2007.06.023
- Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T: Organ-specific autoimmune disease induced in mice by elimination of T-cell subset. I. Evidence for the active participation of T-cells in natural self-tolerance: deficit of a T-cell subset as a possible cause of autioimmune disease. J Exp Med 161;72-87, 1985 https://doi.org/10.1084/jem.161.1.72
- Gambinen E, Torgenson T, Ochs HD: Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Reumatol 15;430-435, 2003 https://doi.org/10.1097/00002281-200307000-00010
- Nardekku DT, Cloute JP, Luk KH, Torrealba J, Warner TF, Callister SM, Schell RF: CD4(+)CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection. Clin Diag Lab Immunol 12;786-792, 2005
- Nguyen LT, Jacobs J, Mathis D, Benoist C: Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 56;509-520, 2007 https://doi.org/10.1002/art.22272
-
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF
$\alpha$ therapy. J Exp Med 200;277-285, 2004 https://doi.org/10.1084/jem.20040165 - Broere F, Wieten L, Koerkamp EI, van Roon JA, Guichelaar T, Lafeber FP, van Eden W: Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes. J Immunol 181;899-906, 2008 https://doi.org/10.4049/jimmunol.181.2.899
-
Forger F, Marcoli N, Gadika S, Moller B, Villiger PM, Ostensen M: Pregnancy induces numerical and funtinal changes of
$CD4+CD25^{high}$ regulatory T cells in patients with rheumatoid arthritis. Ann Rheum Dis 67;984-990, 2008 https://doi.org/10.1136/ard.2007.075283 - 0Kelchtemans H, Geboes L, Mitera T, Huskens D, Leclercq G, Matthys P: Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis 2008
- von Boehmer H: Can studies of tolerance ever lead to therapy? Ann Rheum Dis 65(Suppl 3);iii41-iii43, 2006
- Leipe J, Skapenko A, Lipsky PE, Schulze-Koops H: Regulatory T cells in rheumatoid arthritis. Arthritis Res Ther 7;93, 2005 https://doi.org/10.1186/ar1718
- Wang J, Toes RE: Mechanisms of oral tolerance revisited. Arthritis Res Ther 10;108-109, 2008 https://doi.org/10.1186/ar2402
- Liu MF, Wang CR, Fung LL, Lin LH, Tsai CN: The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 62;312-317, 2005 https://doi.org/10.1111/j.1365-3083.2005.01656.x
- Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V: CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 6;R335-R346, 2004 https://doi.org/10.1186/ar1192
- Behrens F, Himsel A, Rehart S, Stanczyk J, Beutel B, Zimmermann SY, Koehl U, Moeller B, Gay S, Kaltwasser JP, Pfeilschifter JM, Radkeke HH: Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis 66;1151-1156, 2007 https://doi.org/10.1136/ard.2006.068320
-
Cao D, Boerjesson O, Larsson P, Rudin A, Gunnarsson I, Klareskog L, Malmstroem V, Trollmo C: FOXP3 identifies regulatory
$CD25^bright$ CD4+ T cells in rheumatic joints. Scand J Immunol 63;444-452, 2006 https://doi.org/10.1111/j.1365-3083.2006.001755.x - Park MJ, Min SY, Park KS, Cho YG, Cho ML, Jung YK, Park HY, Chang SH, Cho SG, Min JK, Park SH, Kim HY: Indoleamine 2,3-dioxygenase-expresssing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model. Arthritis Res Ther 10;R11, 2008 https://doi.org/10.1186/ar2361
-
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF
$\alpha$ therapy. J Exp Med 200;277-285, 2004 https://doi.org/10.1084/jem.20040165 - Morgan ME, Flierman R, van Duivenvoorde M, Witteveen HJ, van Ewijk W, van Laar JM, de Vries RR, Toes RE: Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum 52;2212-2221, 2005 https://doi.org/10.1002/art.21195
- Nguyen LT, Jacobs J, Mathis D, Benoist C: Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 56;509-520, 2007 https://doi.org/10.1002/art.22272
- Sarkar S, Fox DA: Regulatory T cell defects in rheumatoid arthritis. Arthritis Rheum 56;710-713, 2007 https://doi.org/10.1002/art.22415
- Godebu E, Summers-Torres D, Lin MM, Baaten BJ, Bradley LM: Polyclonal adaptive regulatory CD4 cells that can reverse type 1 diabetes become oligoclonal long-term protective memory cells. J Immunol 181;1798-1805, 2008 https://doi.org/10.4049/jimmunol.181.3.1798
- Tritt M, Sgouroudis E, d'Hennezel E, Albanese A, Piccirillo CA: Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57;113-123, 2008 https://doi.org/10.2337/db06-1700
- Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA: in vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199;1455-1465, 2004 https://doi.org/10.1084/jem.20040139
- Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM: CD25+CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 199;1467-1477, 2004 https://doi.org/10.1084/jem.20040180
- Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA: Expansion of functional endogenous antien-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol 175;3053-3059, 2005 https://doi.org/10.4049/jimmunol.175.5.3053
- Tiittanen M, Huupponen JT, Knip M, Vaarala O: Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro. Diabetes 55;3446-3454, 2006 https://doi.org/10.2337/db06-0132
-
Richer MJ, Straka N, Fang D, Shanina I, Horwitz MS: Regulatory T-cells protect from type 1 diabetes after induction by Coxsackievirus infection in the context of transforming growth factor-
$\beta$ . Diabetes 57;1302-1311, 2008 https://doi.org/10.2337/db07-1460 - Gregori S, Giarratana N, Smiroldo S, Adorini L: Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol 171;4040-4047, 2003 https://doi.org/10.4049/jimmunol.171.8.4040
- Kanagawa O, Militech A, Vaupel BA: Regulation of diabetes development by regulatory T cells in pancreatic islet antigen-specific TCR transgenic nonobese diabetic mice. J Immunol 168;6159-6164, 2002 https://doi.org/10.4049/jimmunol.168.12.6159
- Jaeckel E, von Boehmer H, Manns MP: Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54;306-310, 2005 https://doi.org/10.2337/diabetes.54.2.306
- Lee VW, Wang YM, Wnag YP, Zheng D, Polhill T, Cao Q, Wu H, Alexander IE, Alexander SI, Harris DC: Regulatory immune cells in kidney disease. Am J Physiol Renal Physiol 295;F335-F342, 2008 https://doi.org/10.1152/ajprenal.00077.2008
- Noris M, Casiraghi F, Todeschini M, Cravedi P, Cugini D, Monteferracnte G, Aiello S, Cassis L, Gotti E, Gaspari F, Cattaneo D, Perico N, Remuzzi G: Regulatory T cells and T cell depletion: role of immunosuppressive drugs. J Am Soc Nephrol 18;1007-1018, 2007 https://doi.org/10.1681/ASN.2006101143
- Wolf D, Hochgger K, Wolf AM, Rumpold HF, Gastl G, Tilg H, Mayer G, Gunsilius E, Rsenkranz AR: CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice. J Am Soc Nephrol 16;1360-1370, 2005 https://doi.org/10.1681/ASN.2004100837
- Mahajan D, Wang Y, Qin X, Wang Y, Zheng G, Wang YM, Alexander SI, Harris DC: CD4+CD25+ regulatory T cell protect against injury in an innate murine model of chronic kidney disease. J Am Soc Nephrol 17;2731-2741, 2006 https://doi.org/10.1681/ASN.2005080842
- Wang YM, Zhang GY, Wang Y, Hu M, Wu H, Watson D, Hori S, Alexander IE, Harris DC, Alexander SI: Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. J Am Soc Nephrol 17;697-706, 2006 https://doi.org/10.1681/ASN.2005090978
- Salma AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lecler RI, Pusey CD, Lightstone L: Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 64;1685-1694, 2003 https://doi.org/10.1046/j.1523-1755.2003.00259.x
- Mekal DJ, Alli RS, Geiger TL: IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Proc Natl Acad Sci USA 102;11817-11822, 2005
-
Selvaraj RK, Geiger TL: Mitigation of experimental allergic encephalomyelitis by TGF-
$\beta$ induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance. J Immunol 180;2830-2838, 2008 https://doi.org/10.4049/jimmunol.180.5.2830 - Ochoa-Reparaz J, Riccardi C, Rynda A, Jun S, Callis G, Pascual DW: Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis. J Immunol 178;1791-1799, 2007 https://doi.org/10.4049/jimmunol.178.3.1791
- Mekala DJ, Geiger TL: Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Blood 105;2090-2092, 2005 https://doi.org/10.1182/blood-2004-09-3579
- Ochoa-Reparaz J, Rynda A, Ascon MA, Yang X, Kochetkova I, Riccardi C, Callis G, TrunkleT, Pascual DW: IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen. J Immunol 181;954-968, 2008 https://doi.org/10.4049/jimmunol.181.2.954
- Wang J, Takeuchi H, Sonobe Y, Jin S, Mizuno T, Miyakawa S, Fujiwara M, Nakamura Y, Kato T, Muramatsu H, Muramasu T, Suzumura A: Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc Natl Acad Sci U S A 105;3915-3920, 2008
- Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT: CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198;889-901, 2003 https://doi.org/10.1084/jem.20030171
- Kohm AP, Carpentier PA, Anger HA, Miller SD: Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 169;4712-4716, 2002 https://doi.org/10.4049/jimmunol.169.9.4712
- Gonzalez-Rey E, Fernandex-Martin A, Chorny A, Martin J, Pozo D, Ganea D, Delgado M: Therapeutic effect of vasoactive intestinal peptide on experimental autoimmune encephalomyelitis; down-regulaltion of inflammatory and autoimmune responses. Am J Pathol 168;1179-1188, 2006 https://doi.org/10.2353/ajpath.2006.051081
- Char JG, Coe D, Chen D, Simpson E, Dyson J, Scott D: in vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J Immunol 180;858-869, 2008 https://doi.org/10.4049/jimmunol.180.2.858
-
Venken K, Hellings N, Broekmans T, Hensen K, Rummens JL, Stinissen P: Natural naive CD4+CD25+
$CD127^{low}$ regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol 180;6411-6420, 2008 https://doi.org/10.4049/jimmunol.180.9.6411 - Venken K, Hellings N, Thewissen M, Somers V, Hensen K, Rummens JL, Medaer R, Hupperts R, Stinissen P: Compromised CD4+CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 exxpression at the single-cell level. Immunology 123;79-89, 2008 https://doi.org/10.1111/j.1365-2567.2007.02690.x
- Saresella M, Marventano I, Longhi R, Trabattoni D, Mendozzi L, Caputo D, Clerici M: CD4+CD25+Fox3+ PD-regulatory T cells in acute and stable elapsing-remitting multiple sclerosis and their modulation by therapy. FASEB 22;3500-3508, 2008 https://doi.org/10.1096/fj.08-110650
- Zozulya AL, Wiendl H: The role of regulatory T cells in multiple sclerosis. Nat Clin Prat Neurol 4;384-398, 2008 https://doi.org/10.1038/ncpneuro0832
- Anderton SM, Liblau RS: Regulatory T cells in the control of inflammatory demyelingating diseases of the central nervous system. Curr Opin Neurol 21;248-254, 2008 https://doi.org/10.1097/WCO.0b013e3282febf58
- Danese S, Rutella S: The Janus faces of CD4+CD25+ regulatory T cells in cancer and autoimmunity. Curr Med Chem 14;649-666, 2007 https://doi.org/10.2174/092986707780059599
- Suarez A, Lopez P, Gomez J, Gutierrez C: Enrichment of CD4+CD25high T cell population in SLE patients treated with glucocorticoids. Ann Rheum Dis 65;1512-1517, 2006 https://doi.org/10.1136/ard.2005.049924
- Mellor-Pita S, Citores MJ, Castejon R, Tutor-Ureta P, Yebra-Bango M, Andreu JL, Vargas JA: Decrease of regulatory T cells in patients with systemic lupus erythematosus. Ann Rheum Dis 65;553-554, 2006 https://doi.org/10.1136/ard.2005.044974
- LaCava A: T-regulatory cells in systemic lupus erythematosus. Lupus 17;421-425, 2008 https://doi.org/10.1177/0961203308090028
- Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH: Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford) 47;789-794, 2008 https://doi.org/10.1093/rheumatology/ken108
- Azba NA, Bassyoun IH, Emad Y, Abd El-Wahab GA, Hamdy G, Mashahit MA: CD4+CD25+ regulatory T cells (TREG) in systemic lupus erythematousus (SLE) patients: the possible influence of treatment with corticosteroids. Clin Immunol 127;151-157, 2008 https://doi.org/10.1016/j.clim.2007.12.010
- Kang HK, Michaels MA, Berner BR, Datta SK: Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol 174;3247-3255, 2005 https://doi.org/10.4049/jimmunol.174.6.3247
- Parietti V, Chifflot M, Muller S, Monneaux F: Regulatory T cells and systemic lupus erythematosus. Ann N Y Acad Sci 1108;64-75, 2007 https://doi.org/10.1196/annals.1422.007
- Kang HK, Datta SK: Regulatory T cells in lupus. Int Rev Immunol 25;5-25, 2006 https://doi.org/10.1080/08830180500544480
- Valencia X, Yarboro C, Illei G, Lipsky PE: Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 178;2579-2588, 2007 https://doi.org/10.4049/jimmunol.178.4.2579
- Braat H, McGuirk P, Ten Kate FJ, Hubiregtse I, Dunne PJ, Hommes D, Van Deventer SJ, Mills KH: Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule. Gut 56; 351-357, 2007 https://doi.org/10.1136/gut.2006.099861
- Saruta M, Yu QT, Fleshner PR, Mantel PY, Schmidt-Weber CB, Banham AH, Papadakis KA: Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin Immunol 125;281-290, 2007 https://doi.org/10.1016/j.clim.2007.08.003
- Coombes JL, Maloy KJ: Control of intestinal homeostasis by regulatory T cells and dendritic cells. Seminars Immunol 19;116-126, 2007
- Mottet C, Uhlig HH, Powrie F: cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 170; 3939-3943, 2003 https://doi.org/10.4049/jimmunol.170.8.3939
- Denning TL, Kim G, Kronenberg M: Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis. J Immunol 174;7487-7491, 2005 https://doi.org/10.4049/jimmunol.174.12.7487
- Uhlig HH, Coombes J, Mottet C, Izcue A, Thompson C, Fanger A, Tannapfel A, Fontenof JD, Ramsdell F, Powrie F: Characterization of Foxp3+ CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol 177;5852-5860, 2006 https://doi.org/10.4049/jimmunol.177.9.5852
- Sarkar S, Fox DA: Regulatory T cell defects in rheumatoid arthritis. Arthritis Rheum 56;710-713, 2007 https://doi.org/10.1002/art.22415
- DiPaola RJ, Glass DD, Bijwaard, KE, Shevach EM: CD4+CD25+T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J Immunol 175;7135-7142, 2005 https://doi.org/10.4049/jimmunol.175.11.7135
- Stummvoll GH, DiPaolo RJ, Huter EN, Davidson TS, Glass D, Ward JM, Shevach EM: Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J Immunol 181;1908-1916, 2008 https://doi.org/10.4049/jimmunol.181.3.1908
- Aricha R, Feferman T, Fuchs S, Souroujon MC: Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis J Immunol 180;2132-2139, 2008 https://doi.org/10.4049/jimmunol.180.4.2132
- Isaacs JD: Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future. Rheumatology (Oxford) 47;1461-1468, 2008 https://doi.org/10.1093/rheumatology/ken163
- Sheng JR, Li L, Ganesh BB, Vasu C, Prabhakar BS, Meriggioli MN: Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis. Clin Immunol 128;172-180, 2008 https://doi.org/10.1016/j.clim.2008.03.509
- Meriggioli MN, Sheng JR, Li L, Prabhakar BS: Strategies for treating auto immunity: novel insights from experimental myasthenia gravis. Ann N Y Acd Sci 1132;276-282, 2008 https://doi.org/10.1196/annals.1405.023
- Gang E, Vasu C, Cheatem D, Prabhakar BS: IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-marcrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J Immunol 174;7006-7013, 2005 https://doi.org/10.4049/jimmunol.174.11.7006
- Verginis P, Li HS, Carayanniotis G: Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+ CD25+ T cells. J Immunol 174;7433-7439, 2005 https://doi.org/10.4049/jimmunol.174.11.7433
- McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesk HA, Rapopori B: The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology 148;5724-5733, 2007 https://doi.org/10.1210/en.2007-1024
- Solomou ED, Rezvan K, Mielke S, Malide D, Keyvanfar K, Visconte V, Kajigaya S, Barrett AJ, Young NS: Deficient CD4+CD25+FOXP3+ T regulatory cells in acquired aplastic anemia. Blood 110;1603-1606, 2007 https://doi.org/10.1182/blood-2007-01-066258
- Young NS, Scheinberg P, Calado RT: Aplastic anemia: Curr Opin Hematol 15;162-168, 2008 https://doi.org/10.1097/MOH.0b013e3282fa7470
- Wang J, Toes RE: Mechanisms of oral tolerance revisited. Arthritis Res Ther 10;108-109, 2008 https://doi.org/10.1186/ar2402
- Chorny A, Gonzales-Rey E, Ganea D, Delgado M: Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo: therapeutic applications in autoimmunity and transplantation. Ann NY Acad Sci 1070;190-195, 2006 https://doi.org/10.1196/annals.1317.011
- Delgado M, Chorny A, Gonzales-Rey E, Ganea D: Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J Leukc Biol 78;1327-1338, 2005 https://doi.org/10.1189/jlb.0605299
- Gonzalez-Rey E, Fernandez-Martin A, Chorney A, Delgado M: Vasoactive intestinal peptide induces CD4+, CD25+ T regulatory cells with therapeutic effect in collagen-induced arthritis. Arthritis Rheum 54;864-876, 2006 https://doi.org/10.1002/art.21652
- Delgado M, Chorny A, Gonazalez-Rey E, Ganea D: Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J Leukc Biol 78;1327-1338, 2005 https://doi.org/10.1189/jlb.0605299
- Delgado M, Toscano MG, Benabedellah K, Cobo M, O'Valle F, Gonzales-Rey E, Matin F: in vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis. Arthritis Rheum 58;1026-1037, 2008 https://doi.org/10.1002/art.23283
- Broere F, Wieten L, Koerkamp EI, van Roon JA, Guichelaar T, Lafeber FP, van Eden W: Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes. J Immunol 181;899-906, 2008 https://doi.org/10.4049/jimmunol.181.2.899
-
Forger F, Marcoli N, Gadika S, Moller B, Villiger PM, Ostensen M: Pregnancy induces numerical and functional changes of
$CD4+CD25^{high}$ regulatory T cells in patients with rheumatoid arthritis. Ann Rheum Dis 67;984-990, 2008 https://doi.org/10.1136/ard.2007.075283 - Kelchtemans H, Geboes L, Mitera T, Huskens D, Leclercq G, Matthys P: Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis doi:10.1136, 14 May 2008
- Radbruch A, Thiel A: Cell therapy for autoimmune diseases: does it have a future? Ann Rheumatic Dis 63(Suppl 2);ii96-ii101, 2004
- O'connor RA, Anderton SM: Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J Neuroimmunol 193;1-11, 2008 https://doi.org/10.1016/j.jneuroim.2007.11.016
- Que-Gewirth NS, Sullenger BA: Gene therapy progress and prospects: RNA aptamers. Gene Ther 14;283-291, 2007 https://doi.org/10.1038/sj.gt.3302900
- Venken K, Hellings N, Broekmans T, Hensen K, Rummens JL, Stinissen P: Natural naive CD4+CD25+ CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol 180;6411-6420, 2008 https://doi.org/10.4049/jimmunol.180.9.6411
- Reynolds AD, Banerjee R, Liu J, Gendelman HE, Mosley RL: Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. J Leukoc Biol 82;1083-1094, 2007 https://doi.org/10.1189/jlb.0507296
- Karagiannidis C, Akdis M, Holopainen P, Wooley NJ, Hense G, Ruckert B, Mantel PY, Menz G, Akdis CA, Blasser K, Schmidt-Weber CB. Glucoorticoids upregulated FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 114;1425-1433, 2004 https://doi.org/10.1016/j.jaci.2004.07.014
- Proft T, Fraser JD: Bacterial superantigens. Clin Exp Immunol 133;299-306, 2003 https://doi.org/10.1046/j.1365-2249.2003.02203.x
- Ou LS, Goleva E, Hall C, Leung DT: T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 113;756-763, 2004 https://doi.org/10.1016/j.jaci.2004.01.772
- Goleva E, Cardona ID, Ou LS, Leung DY.: Factors that regulate naturally occurring T regulatory cell-mediated suppression. J Allergy Clin Immunol 116;1000-1094, 2005 https://doi.org/10.1016/j.jaci.2005.08.011
- Feunou P, Vanwetswinkel S, Gaudray F, Goldman M, Matthys P, Braun MY: Foxp3+CD25+T regulatory cells stimulate IFN-gamma-independent CD152-mediated activation of tryptophan catabolisms that provides dendritic cells with immune regulatory activity in mice unresponsive to staphylococcal enterotoxin B. J Immunol 179;910-917, 2007 https://doi.org/10.4049/jimmunol.179.2.910
- Battaglia M, StabiliniA, Roncarolo MG: Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105;4743-4748, 2005 https://doi.org/10.1182/blood-2004-10-3932
- Chin KM, Foss FM: Biologic correlates of response and survival in patients with cutaneous T cell lymphoma treated with denileukin diftitox. Clin Lymphoma Myeloma 7;199-204, 2006 https://doi.org/10.3816/CLM.2006.n.059
- Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG: Rapamycin promotes expansion of functional CD4+CD25+ FOXP3+ regulatory T cells of both healthy subject and type 1 diabetic patients. J Immunol 177;8338-8347, 2006 https://doi.org/10.4049/jimmunol.177.12.8338
- Mira E, Leon B, Barber DF, Jimenez-Baranda S, Goya I, Almonacid L, Marquez G, Zaballos A, Martinex-A C, Stein JV, Ardavin C, Manes S: Statins induce regulatory T cell recruitment via CCL1 dependent pathway. J Immunol 181;3524-3534, 2008 https://doi.org/10.4049/jimmunol.181.5.3524