The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

A Crossover Clinical Trial to Determine the Effect of Siguan(Four Gates) Points on Gastrointestinal Motility Suppressed by Loperamide Administration

Loperamide로 억제된 위장관 운동에 대한 사관혈의 자침효과: 무작위배정, 단일눈가림, 교차설계, 대조 임상시험

  • Oh, Dal-Seok (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Jung, So-Young (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Kim, Ae-Ran (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Kang, Wee-Chang (Dept. of Information & Statistics, Daejeon University) ;
  • Park, Ji-Eun (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Koo, Chang-Mo (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Choi, Jun-Yong (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Jung, Hee-Jung (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Choi, Sun-Mi (Acupuncture Moxibustion & Meridian Research Team, Department of Medical Research, Korean Institute of Oriental Medicine) ;
  • Son, Chang-Gue (East-West Cancer Center, Dunsan Hospital of Oriental Medical College, Daejeon University)
  • 오달석 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 정소영 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 김애란 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 강위창 (대전대학교 통계학과) ;
  • 박지은 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 구창모 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 최준용 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 정희정 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 최선미 (한국한의학연구원 의료연구부 침구경락연구거점기반구축사업팀) ;
  • 손창규 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2008.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : To investigate the therapeutic effect of manual acupuncture at Siguan (four gates, bilateral LI4 and LR3) on suppression of gastrointestinal motility. Methods : A single blind, randomized, sham-acupuncture controlled, crossover study was conducted. Twenty healthy male subjects were admitted at hospital, and gastrointestinal motility suppression was induced by loperamide administration. Just after intake of 20 radio-markers, four gates or sham acupoint treatments were administered every 12 hours, 4 times over 48 hours. Gastrointestinal motility was evaluated by radiographic distribution of the radiomarkers at stomach or ileum, ascending, transverse, descending colon, sigmoid/rectum, and outside body at serial time points (0, 6, 12, 24, and 48 h). Results : Four gates acupuncture activated gastrointestinal movement as evidenced by significantly changed distributionof radio-makers at 6, 12, and 48 hours (P < 0.0001, P = 0.001, and P = 0.03, respectively) in Cochran-Mantel-Haenszel statistics. No serious adverse events occurred in either group. Conclusions : This study showed a scientific clinical relevance of four gates acupuncture to gastrointestinal disorders.

Keywords