Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
권호 표지

No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients

한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구

  • Jang, Ho Joon (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
  • Moon, Hyun-Il (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
  • Lee, Yeon Jung (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
  • Kim, Im-Yel (Keyo Hospital) ;
  • Lee, In-Sang (Jinju Mental Hospital) ;
  • Seo, Han-Gil (Jinju Mental Hospital) ;
  • Kim, Ki-Hoon (Department of Biomedical Engineering, Yonsei University) ;
  • Shin, Tae-Min (Department of Biomedical Engineering, Yonsei University) ;
  • Park, Byung-Lae (SNP Genetics) ;
  • Shin, Hyung Doo (SNP Genetics) ;
  • Han, Sun Ho (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
  • Han, Sang-Woo (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
  • Woo, Sung-Il (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University)
  • 장호준 (순천향대학교 의과대학 신경정신과학교실) ;
  • 문현일 (순천향대학교 의과대학 신경정신과학교실) ;
  • 이연정 (순천향대학교 의과대학 신경정신과학교실) ;
  • 김임렬 (계요병원) ;
  • 이인상 (진주정신병원) ;
  • 서한길 (진주정신병원) ;
  • 김기훈 (연세대학교 의공학과) ;
  • 신태민 (연세대학교 의공학과) ;
  • 박병래 ((주)에스엔피 제네틱스) ;
  • 신형두 ((주)에스엔피 제네틱스) ;
  • 한선호 (순천향대학교 의과대학 신경정신과학교실) ;
  • 한상우 (순천향대학교 의과대학 신경정신과학교실) ;
  • 우성일 (순천향대학교 의과대학 신경정신과학교실)
  • Published : 2008.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was $4.39{\pm}0.33$(mean${\pm}$s.d.) and that of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. Conclusions : The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.

Keywords