Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Theoretical Consideration of the Modified Haldane Model of the Substrate Inhibition in the Microbial Growth Processes

미생물 성장 공정에서의 기질 저해에 관한 modified Haldane 모델의 이론적 고찰

  • Hwang, Young-Bo (School of Material Science & Nano Chemical Engineering, Kunsan National University)
  • 황영보 (군산대학교 공과대학 신소재.나노화학공학부)
  • Received : 2008.01.09
  • Accepted : 2008.03.26
  • Published : 2008.06.10
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Abstract

This paper deals with the theoretical derivation of the modified Haldane model of the substrate inhibition in the microbial growth processes. Based on the biological concepts of substrate-receptor complex working mechanisms, a new microbial kinetics of N-fold multiplex substrate inhibition and its generalization has been considered theoretically, which is natural expansion of the simple substrate inhibition mechanism in the enzyme reaction. As a result, the modified Haldane model of the substrate inhibition turns out to be a well-designed four-parameter kinetic model with a biological constant of the total substrate inhibition concentration.

본 논문은 미생물 성장 공정에서의 기질 저해에 관한 modified Haldane 모델의 이론적 유도를 다룬다. 생물학적 개념인 기질-수용체 복합체의 작동 메커니즘을 바탕으로 새로운 미생물학적 동특성인 N-중첩된 다중 기질 저해 모델의 유도와 더불어 일반화가 이론적으로 고찰되었는데, 이것은 효소 반응에서의 단순 기질 저해 메커니즘이 자연스럽게 확장된 것이다. 결과적으로, 본 기질 저해에 관한 modified Haldane 모델은 완전저해 기질농도라는 생물학적 상수를 포함하고 있는, 잘 설계된 4-파라메터 동특성 모델임이 밝혀졌다.

Keywords

References

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